Which oncogene is associated with neuroblastoma?

Neuroblastoma cells sometimes have extra copies (amplification) of the MYCN oncogene, which is often a sign that the tumor will grow quickly and might be harder to treat. If the NTRK1 gene (which makes the TrkA protein) is overactive in neuroblastoma cells, the neuroblastoma might have a better outlook.

What is MYCN in neuroblastoma?

As MYCN is a master transcription factor important for both proper cell proliferation and apoptosis, a persistent expression of MYCN during the maturation stages of sympathoadrenal precursors could result in inhibition of apoptotic signaling and maintained proliferation that ultimately could result in the development …

What is the difference between MYC and MYCN?

Expression of MYCN is tissue specific, and is found during early developmental stages, whereas expression of MYC is more generalized (Fig. 1C). For example, expression of MYCN is highest in forebrain, kidney, and hindbrain of newborn mice, and is virtually absent in all tissues of adult mice.

What does MYCN stand for?


Aliases MYCN, MODED, N-myc, NMYC, ODED, bHLHe37, v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog, MYCN proto-oncogene, bHLH transcription factor, MYCNsORF, MYCNsPEP
External IDs OMIM: 164840 MGI: 97357 HomoloGene: 3922 GeneCards: MYCN

Is Mycn an oncogene?

The MYCN gene belongs to a class of genes known as oncogenes. When mutated, oncogenes have the potential to cause normal cells to become cancerous. The MYCN gene is a member of the Myc family of oncogenes.

What gene causes neuroblastoma?

Hereditary neuroblastoma is caused by changes in one of two genes: ALK or PHOX2B. Genes carry information telling cells within the body how to function. The ALK and PHOX2B genes control how and when nerve cells grow, divide and die.

How does the ras gene convert from a proto oncogene to an oncogene?

In animal models, it has been shown that mutations that convert ras proto-oncogenes to oncogenes are caused by chemical carcinogens, providing a direct link between the mutagenic action of carcinogens and cell transformation.

What do proto-oncogenes normally do?

Introduction to Proto-oncogenes Often, proto-oncogenes encode proteins that function to stimulate cell division, inhibit cell differentiation, and halt cell death. All of these processes are important for normal human development and for the maintenance of tissues and organs.

Is MYCN an oncogene?

What chromosome is MYCN on?

chromosome 2
(1994) used fluorescence in situ hybridization in the study of 5 human neuroblastoma cell lines to demonstrate that, in addition to amplified MYCN in HSRs or double minutes, single-copy MYCN was present at the normal position on chromosome 2.

What is the MYCN gene?

The MYCN gene is a member of the Myc family of oncogenes. These genes play important roles in regulating cell growth and division (proliferation) and the self-destruction of cells (apoptosis).