Which of the following is an indirect sympathomimetic drug?

Indirect sympathomimetic drugs

Overview of indirect sympathomimetics
Drugs Action
Amphetamines Yes Yes
Cocaine Yes No
Ephedrine Yes Yes

Which of the following is indirect-acting adrenergic drugs?

Indirect-acting sympathomimetic drugs include ephedrine, which occasionally is used as a nasal decongestant, and amphetamines. These substances act mainly through mechanisms that result in the release of catecholamines from their storage areas in nerve terminals.

Which of the following is direct-acting sympathetic Agnets?

Direct-acting Direct stimulation of the α- and β-adrenergic receptors can produce sympathomimetic effects. Salbutamol is a widely used direct-acting β2-agonist. Other examples include phenylephrine, isoproterenol, and dobutamine.

Is phenylephrine direct or indirect-acting?

Phenylephrine is a direct-acting sympathomimetic amine chemically related to adrenaline and ephedrine with potent vasoconstrictor property. Phenylephrine is a post-synaptic alpha-adrenergic receptor agonist that causes vasoconstriction, increases systolic/diastolic pressures, reflex bradycardia, and stroke output.

What is indirect acting sympathomimetics?

Sympathomimetics are drugs that mimic the stimulation of the sympathetic nervous system. They are classified as directly acting (act directly on α or β receptors), indirectly acting (act by providing more norepinephrine to act on α or β receptors), or mixed acting (act by both mechanisms).

Is propranolol a sympathomimetic drug?

Interactions of sympathomimetic drugs, propranolol and phentolamine, on atrial refractory period and contractility.

Is epinephrine direct or indirect?

Catecholamines, norepinephrine, and epinephrine are direct-acting and nonselective adrenergic agonists. Indirect-acting agonists cause the release of the neurotransmitter norepinephrine from sympathetic nerve terminals. Adrenergic receptors are classified into three major types: α1-, α2-, and β-adrenergic receptors.

Which is indirect-acting adrenergic agonist?

Indirect-acting adrenergic agonists are compounds that cause activation of adrenergic receptors by mechanisms other than their direct binding. In general, indirect agonists act to promote release of endogenously-stored norepinephrine from presynaptic terminals.

What is the difference between direct and indirect sympathomimetics?

What is the difference between direct-acting and indirect acting parasympathomimetics?

– Direct-acting parasympathomimetics bind directly to cholinergic receptors. – Indirect-acting parasympathomimetics inhibit the enzyme acetylcholinesterase, thereby increasing the concentration of acetylcholine in the synaptic cleft. They are further subdivided into reversible and irreversible agents.

What are indirect acting sympathomimetic agents?

Indirectly Acting Sympathomimetics

  • Drug Class: Indirectly Acting Sympathomimetic (a byproduct of tyrosine metabolism)
  • Mechanism of Action: Tyramine is taken up into nerve terminals by NET (the norepinephrine reuptake transporter) and causes the release of catecholamines.

What is the difference between epinephrine and phenylephrine?

Epinephrine is a vasoconstrictor, which is commonly used to prevent or minimize bleeding during hypospadias surgery. Phenylephrine is another vasoconstrictor with more specific actions on vessels and fewer systemic adverse effects.