What is the role of interleukin 8?

Abstract. Interleukin-8 (IL-8) is a chemoattractant cytokine produced by a variety of tissue and blood cells. Unlike many other cytokines, it has a distinct target specificity for the neutrophil, with only weak effects on other blood cells. Interleukin-8 attracts and activates neutrophils in inflammatory regions.

Which interleukin can stimulate angiogenesis?

Interleukin-17 promotes angiogenesis and tumor growth.

Is IL-8 proinflammatory or anti inflammatory?

Interleukin 8 (IL-8) is a proinflammatory cytokine with proangiogenic, proliferative, and promotility activities. It is produced by multiple cell types and has been associated with tumor progression in several types of cancer.

What is the receptor for IL-8?

Neutrophils are the main target cells for IL-8, and contain a large number of IL-8 receptors on their cell surfaces. Binding causes a neutrophil to migrate to the site of infection.

Where is interleukin 8 produced?

IL-8 (CXCL-8) is a chemokine of the CXC family and it is actively produced by monocytes/macrophages and other cell types like endothelial cells, epithelial cells and airways smooth muscle cells [189,190].

Is interleukin 8 inflammatory?

Interleukin 8 (IL-8) is a pro-inflammatory cytokine that has a role in neutrophil activation and has been identified within the pathogenesis and progression of this disease.

Is IL-8 a Th1 cytokine?

For example, TNF-alpha, IL-1, and IL-8 as Th1-associated cytokines and IL-6 as Th2-associated cytokines have been assigned in some investigations [30, 31]. In this preliminary study, TNF-alpha, IL-1, IL-8, and IL-6 were assigned to Th1 and Th2 cytokines, respectively.

How does interleukin cause inflammation?

IL-6 in combination with its soluble receptor sIL-6Rα, dictates the transition from acute to chonic inflammation by changing the nature of leucocyte infiltrate (from polymorphonuclear neutrophils to monocyte/macrophages).

What are interleukins in immune system?

Interleukins (IL) are a type of cytokine first thought to be expressed by leukocytes alone but have later been found to be produced by many other body cells. They play essential roles in the activation and differentiation of immune cells, as well as proliferation, maturation, migration, and adhesion.