What does MSCRAMM stand for?

MSCRAMM (acronym for “microbial surface components recognizing adhesive matrix molecules”) adhesin proteins mediate the initial attachment of bacteria to host tissue, providing a critical step to establish infection.

How do MSCRAMMs work?

MSCRAMMs have a variety of roles in infection and host colonization (Table 3). Recent advances are discussed below. They promote bacterial adhesion to host tissue and cells, survival in the blood stream during the bacteremic phase of invasive infection, and the formation of abscesses in the skin and in internal organs.

Are MSCRAMMs adhesins?

IE pathogens possess several surface adhesins that mediate attachment to extracellular matrix proteins of the host. These adhesins are collectively referred to as MSCRAMMs, for microbial surface component reacting with adhesive matrix molecules.

Why coagulase test is done?

The coagulase test is useful for differentiating potentially pathogenic Staphylococci such as Staphylococcus aureus from other Gram positive, catalase-positive cocci.

Does MRSA form endospores?

Description. Staphylococcus aureus is a Gram-positive, non-spore forming, nonmotile, cocci bacterium that colonizes in yellow clusters [8].

What are the 2 types of coagulase test?

Coagulase is of two types; free coagulase and bound coagulase, each of which is detected by different methods. The bound coagulase is called the clumping factor and is detected rapidly by a slide test. The free coagulase, in turn, is detected in the test tube as a result of the formation of a clot.

What bacteria is coagulase positive?

Bacteria in the genus Staphylococcus are pathogens of man and other mammals. Traditionally they were divided into two groups on the basis of their ability to clot blood plasma (the coagulase reaction). The coagulase-positive staphylococci constitute the most pathogenic species S aureus.

What does Protein A and G bind to?

Protein A/G binds to all subclasses of human IgG, making it useful for purifying polyclonal or monoclonal IgG antibodies whose subclasses have not been determined. In addition, it binds to IgA, IgE, IgM and (to a lesser extent) IgD.