What are the limitations of fMRI?

There are certain disadvantages of fMRI which include,

  • It is expensive compared to other scans.
  • The patient has to stay still to capture clear images.
  • Patient’s movements can affect the quality of images.

Why is fMRI limited?

Resolution in fMRI is limited primarily by SNR because of the necessity for rapid acquisition of time series information. For MRI, SNR ∝ p 2 w T acq N , where p is the pixel size, w the slice thickness, Tacq is the k-space readout time and N is the number of time frames.

What are the limitations of brain imaging techniques?


  • Expensive to use.
  • Cannot be used in patients with metallic devices, like pacemakers.
  • Cannot be used with uncooperative patients because the patient must lie still.
  • Cannot be used with patients who are claustrophobic (afraid of small places).

What is the bold response in fMRI?

The blood-oxygen-level-dependent (BOLD) signal, detected in fMRI, reflects changes in deoxyhemoglobin driven by localized changes in brain blood flow and blood oxygenation, which are coupled to underlying neuronal activity by a process termed neurovascular coupling.

What are strengths and weaknesses of using fMRI in a research?

fMRI is easy to use, and the images it produces are very high resolution (as detailed as 1 millimeter). Also, compared to the traditional questionnaire methods of psychological evaluation, fMRI is far more objective. Yet fMRI also has its disadvantages. First, it’s expensive.

What can fMRI not measure?

FMRI is an indirect measure of neuronal activity. It does not measure neural, electrical or chemical changes but instead detects hemodynamic effects using blood oxygenation level-dependent (BOLD) responses that are delayed and dispersed in time.

What is the limiting factor for temporal resolution of MRI?

Abstract. In fMRI, images can be collected in a very short time; therefore, high temporal resolution is possible in principle. However, the temporal resolution is limited by a blurred intrinsic hemodynamic response and a finite signal-to-noise ratio.

What factors affect spatial resolution of fMRI?

The weaker gradients on human scanners and the limitations of peripheral nerve stimulation (which limits the maximum gradient slew rate and maximum EPI gradient amplitude) restrict the maximum spatial resolution, and most laminar fMRI studies in humans use an isotropic resolution of 0.75–0.8 mm.

What is one disadvantage of MRI as a brain imaging technique?

Advantages and Disadvantages of fMRI and MRI^ MRI and fMRI both involve no radiation, and there are no known side effects caused by the magnetic fields and radio waves. The main risk with MRI is that the presence of metal in the body (such as pacemakers or other implants) can be a safety hazard.

Is fMRI expensive?

Relative to EEG-based techniques, fMRI is expensive. MRI scanners cost millions of dollars, and their maintenance can be expensive as well. However, PET and MEG-based techniques have similar costs for implementation.

What is BOLD MRI imaging?

Blood Oxygenation Level Dependent (BOLD) imaging is a technique that is commonly used for measuring brain activity in humans using magnetic resonance imaging (MRI). Blood supplies oxygen to brain cells. When these cells are active, there is an increase in blood flow and blood oxygen in the surrounding area.

What is BOLD effect?

The BOLD effect is directly related to the concentration of deoxy-hemoglobin, which varies from less than 2% in arterial blood to greater than 40% in venous blood. Deoxyhemoglobin is strongly paramagnetic due to 4 unpaired electrons at each iron center.