Which drugs can cause fixed drug eruption?

The major categories of causative agents of fixed drug eruption include antibiotics, antiepileptics, nonsteroidal anti-inflammatory agents, sildenafil, and phenothiazines, although numerous other agents and certain foods such as cashews and licorice have also been reported as causative agents.

What is the treatment for fixed drug eruption?

The main goal of treatment is to identify the causative agent and avoid it. Treatment for fixed drug eruptions (FDEs) otherwise is symptomatic. Systemic antihistamines and topical corticosteroids may be all that are required. In cases in which infection is suspected, antibiotics and proper wound care are advised.

What type of hypersensitivity reaction is involved in a fixed drug eruption when it occurs in the oral cavity?

Fixed-drug eruption (FDE) is an unusual and rare adverse drug reaction. This type of reaction is actually a delayed type of hypersensitivity reaction that occurs as lesions recurring at the same skin site due to repeated intake of an offending drug.

What is a fixed drug eruption mean?

INTRODUCTION. Fixed drug eruption (FDE) is a distinctive type of cutaneous drug reaction that characteristically recurs in the same locations upon re-exposure to the offending drug.

Can Tylenol cause fixed drug eruption?

Clinicians should be aware of the ability of acetaminophen to induce fixed drug eruption that may clinically take several aspects and may be misdiagnosed.

What medications can cause skin lesions?

Drugs that are more likely to cause this type of eruption include penicillins, cephalosporins, sulfonamides, anticonvulsants, and allopurinol (TABLE 1).

Can vitamins cause fixed drug eruption?

Drug reactions related to multivitamins are rare and very few cases have been reported. This is a case of a young woman who developed bullous fixed drug eruption to multivitamins.

Is fixed drug eruption an allergy?

Fixed drug eruption is a distinctive cutaneous allergic reaction that characteristically recurs at the same site(s) on re-exposure to the medication or other chemical agent.

Do fixed drug eruptions go away?

Fixed drug eruptions (FDE) are a distinct type of drug eruptions that appear as pruritic, well circumscribed, round or oval-shaped, erythematous macules or edematous plaques, and characteristically recur at the same sites upon re-exposure to the offending drug. They usually resolve spontaneously with hyperpigmentation.

Can ibuprofen cause fixed drug eruption?

Fixed drug eruptions have been associated in up to 40 percent of cases with non-steroidal inflammatory drugs, including ibuprofen.

What medications cause skin necrosis?

Skin necrosis is a rare but debilitating complication of treatment with vitamin K antagonist anticoagulants such as warfarin. A clinically similar syndrome has been reported less frequently with heparin therapy.

What does a rash from a drug allergy look like?

Drug rashes can appear as a variety of skin rashes, including pink to red bumps, hives, blisters, red patches, pus-filled bumps (pustules), or sensitivity to sunlight. Drug rashes may involve the entire skin surface, or they may be limited to one or a few body parts. Itching is common in many drug rashes.