What is the mechanism of action of etoposide?

Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death.

What is etoposide and cisplatin?

What is etoposide and cisplatin? Etoposide and cisplatin chemotherapy (EP) is a combination chemotherapy treatment used to treat different types of cancer. It is best to read this information with our general information about chemotherapy and the type of cancer you have.

What goes first etoposide or cisplatin?

Schedule. Typically, these two drugs are given one after the other on the same day. Cisplatin + Etoposide are usually given at an outpatient infusion center, allowing the person to go home afterwards.

How does etoposide induce apoptosis?

Low or high concentrations of etoposide have different effects on transcriptional regulation by p53. Tumor suppressor protein p53 plays an important role in DNA damage-induced apoptosis, at least partly by acting as a transcription factor to direct the expression of apoptotic mediators.

How does cisplatin act as anticancer?

Cisplatin binds to the N7 reactive center on purine residues and as such can cause deoxyribonucleic acid (DNA) damage in cancer cells, blocking cell division and resulting in apoptotic cell death. The 1,2-intrastrand cross-links of purine bases with cisplatin are the most notable among the changes in DNA.

What is cisplatin antineoplastic agent?

Cisplatin is an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug. This medication is classified as an “alkylating agent.” (For more detail, see “How Cisplatin Works” section below).

What type of drug is etoposide?

Etoposide is in a class of medications known as podophyllotoxin derivatives. It works by slowing or stopping the growth of cancer cells in your body.

How does cisplatin work with radiation?

Cisplatin sensitizes cancer cells to ionizing radiation via inhibition of non-homologous end joining.

Why is carboplatin and etoposide given together?

Each of the medications in carboplatin + etoposide are designed to target and kill rapidly dividing lung cancer cells. Goals of therapy: Carboplatin + etoposide is given to shrink tumors and alleviate symptoms of lung cancer.

What is the drug etoposide?

Etoposide is used in combination with other medications to treat a certain type of lung cancer (small cell lung cancer; SCLC). Etoposide is in a class of medications known as podophyllotoxin derivatives. It works by slowing or stopping the growth of cancer cells in your body.