What is pemphigus Vegetans?

Pemphigus vegetans is a rare variant of pemphigus vulgaris characterized by heaped up, cauliflower-like vegetating plaques in the flexures. [1] The disorder affects chiefly middle-aged adults. Lesions are primarily flexural, although vegetations may occur at any site.

How do you treat pemphigus Vegetans?

There’s currently no cure for pemphigus vulgaris (PV), but treatment can help keep the symptoms under control. The main aim of treatment is to heal the blisters and prevent new ones forming. Steroid medication (corticosteroids) plus another immunosuppressant medication are usually recommended.

What causes pemphigus Vegetans?

Pemphigus vulgaris occurs when the immune system mistakenly makes antibodies against proteins in healthy skin and mucous membranes. The antibodies break down the bonds between the cells, and fluid collects between the layers of the skin. This leads to blisters and erosions on the skin.

What drugs can cause pemphigus?

Drugs that cause pemphigus include:

  • Thiol drugs, including penicillamine, captopril.
  • Antibiotics: penicillins, cephalosporins, vancomycin.
  • Antihypertensive drugs: other angiotensin-converting enzyme inhibitors such as cilazapril, lisinopril, enalapril.
  • Piroxicam.

How long can you live with pemphigus?

Untreated, pemphigus vulgaris is often fatal because of the susceptibility to infection and fluid and electrolyte disturbances. Most deaths occur during the first few years of disease, and, if the patient survives 5 years, the prognosis is good.

Can you live a normal life with pemphigus?

For most people, the disease can be controlled with treatment. Many can eventually stop their treatment for a while. Before medicines like prednisone and azathioprine were used to treat pemphigus, a person lived about 5 years after getting pemphigus vulgaris, the most common type.

What triggers pemphigus?

Pemphigus vulgaris is not fully understood. Experts believe that it’s triggered when a person who has a genetic tendency to get this condition comes into contact with an environmental trigger, such as a chemical or a drug. In some cases, pemphigus vulgaris will go away once the trigger is removed.

What antibody causes pemphigus?

Pemphigus vulgaris This form is associated with the presence of IgG antibodies against desmoglein 3, with or without antidesmoglein 1 antibodies. Patients with both antibodies tend to have more severe or active disease;11 desmoglein 1 antibodies tend to decrease more rapidly on treatment than desmoglein 3 antibodies.

Can stress cause pemphigus?

For those of you who have any one of the pemphigus/pemphigoid (P/P) related skin diseases, stress is the number one factor in flare-ups occurring.

How does pemphigus cause death?

One study of 159 patients with pemphigus vulgaris admitted to the hospital from 1980 to 1998 documented a mortality rate of 8.8 % (14 patients) during hospital treatment; the main causes of death were cardiopulmonary failure and sepsis (Ljubojevic et al., 2002).

What foods trigger pemphigus?

You want to avoid hard foods like chips, chunky peanut butter, nuts, crisp vegetables like raw carrots, and fruit. Other foods that can cause new mouth sores include spicy foods, steaming-hot foods, and acidic foods like tomatoes and citrus fruits.