What is hyper-CVAD regimen?

An abbreviation for a chemotherapy combination used to treat some types of acute lymphoblastic leukemia (ALL) and non-Hodgkin lymphoma (NHL). Hyper-CVAD regimen includes the drugs cyclophosphamide, vincristine sulfate, doxorubicin hydrochloride (Adriamycin), and dexamethasone.

How is hyper-CVAD administered?

Hyper-CVAD is given as hyperfractionated therapy, in which the total daily dose is divided into smaller doses and given more than once a day. This combination may also be used with other drugs or treatments or to treat other types of cancer.

How often is hyper-CVAD given?

HyperCVAD Part A is alternated with HyperCVAD Part B every 21 days. This sometimes takes longer if waiting for normal blood counts recover after the previous cycle. When both Part A and Part B are completed, this is known as one Cycle.

What is Calgb regimen?

The CALGB 19802 regimen is characterized by early dose intensification of daunorubicin during induction and post-remission therapy and high-dose cytarabine and methotrexate during post-remission therapy.

What Calgb 10403?

CALGB 10403 treatment consisted of induction, consolidation, interim maintenance, delayed intensification, and long-term maintenance therapy (detailed dosing schedule provided in Figure 1) and replicated exactly 1 arm of the Children’s Oncology Group (COG) randomized study AALL0232 for high-risk childhood ALL.

How long is a cycle of Hyper-CVAD?

Your course of chemotherapy You usually have a course of several cycles of treatment over a few months Each cycle of hyper-CVAD lasts 21 days.

What is Gmall protocol?

The GMALL study group developed these protocols based on concepts employed successfully in the treatment of paediatric mature B-ALL. All used short, alternating cycles of intensive chemotherapy (in an ABABAB pattern) that included high doses of methotrexate and cyclophosphamide.

What is BFM protocol?

A modified version of the standard Berlin-Frankfurt-Munich (BFM) protocol for pediatric ALL was developed to achieve balance between toxicity and favorable response rates. Modification included a dose reduction of asparaginase and methotrexate during the consolidation and reinduction phase.

How is HiDAC administered?

HiDAC is administered as a rapid intravenous infusion as patients tolerate higher doses better than when given as a slow intravenous injection. You generally receive treatment with cytarabine in hospital and you may have to stay in until your blood counts recover.

What is Capizzi style methotrexate?

Introduction The Capizzi-style methotrexate (MTX) is an integral part of acute. lymphoblastic leukemia (ALL) treatment.