What is FSGS medical term?

What is FSGS medical term?

Focal segmental glomerulosclerosis (FSGS) is a disease in which scar tissue develops on the glomeruli, the small parts of the kidneys that filter waste from the blood.

Is FSGS a nephrotic syndrome?

FSGS is a rare disease that attacks the kidney’s filtering units (glomeruli) and causes serious scarring, leading to permanent kidney damage and even kidney failure. FSGS is one of the causes of a serious condition known as Nephrotic Syndrome.

Is FSGS an inflammatory disease?

Rationale: Inflammatory demyelinating neuropathies such as Guillain–Barré syndrome (GBS), chronic inflammatory demyelinating polyneuropathy (CIDP), and focal segmental glomerulosclerosis (FSGS) are autoimmune disorders that may have a common pathogenesis.

What does focal segmental mean?

“Focal” means that some of the glomeruli become scarred. Others remain normal. “Segmental” means that only part of an individual glomerulus is damaged.

What stage of kidney disease is FSGS?

Focal segmental glomerulosclerosis (FSGS) is one of the most common forms of acquired glomerular disease leading to end stage kidney disease (ESKD).

How many types of FSGS are there?

Another classification system, called the Columbia Classification, breaks down FSGS into five subtypes based on the appearance (morphology) of the FSGS lesions affecting the glomeruli as seen under a microscope. These five variants are: perihilar, cellular, tip, collapsing, and FSGS not otherwise specified.

What drugs cause FSGS?

Other causes of secondary FSGS include the use of certain medications or drugs that have been shown to damage podocytes, such as interferon, bisphosphonates, anabolic steroids, heroin, anthracyclines, calcineurin inhibitors, lithium, and sirolimus.

Is FSGS an autoimmune disorder?

What Causes FSGS? FSGS can be a result of an autoimmune disease, in which the body attacks itself without cause, or the result of a pre-existing medical condition such as the following: Kidney defects from birth. Urine back-ups in the kidney.

Is FSGS autoimmune?

FSGS can be a result of an autoimmune disease, in which the body attacks itself without cause, or the result of a pre-existing medical condition such as the following: Kidney defects from birth. Urine back-ups in the kidney. Obesity.

How common is FSGS?

Focal segmental glomerulosclerosis is estimated to affect about 7 people per million people in the general population, although specific incidence rates vary in different populations. FSGS accounts for about 40% of adults with nephrotic syndrome and about 20% of children with nephrotic syndrome.