What is considered low ceruloplasmin?

The normal range for a ceruloplasmin serum test is 20 to 35 milligrams per deciliter (mg/dL). If you have Wilson disease, your ceruloplasmin level will probably be below 10 mg/dL. Low ceruloplasmin might also mean Menkes disease. This is a genetic disorder that makes it hard for your body to absorb copper.

What is the normal range for ceruloplasmin?

The normal range for adults is 14 to 40 mg/dL (0.93 to 2.65 µmol/L). Normal value ranges may vary slightly among different laboratories.

How low is ceruloplasmin in Wilson’s disease?

Approximately 90% of all patients with Wilson disease have ceruloplasmin levels of less than 20 mg/dL (reference range, 20-40 mg/dL). (Ceruloplasmin is an acute phase reactant and may be increased in response to hepatic inflammation, pregnancy, estrogen use, or infection.)

What is the level of ceruloplasmin in Wilson’s disease?

If suspicion of Wilson disease is high, order a ceruloplasmin level. It will be less than 20 mg/dL (normal 20 mg/dL to 40 mg/dL). Urinary copper levels will be raised more than 100 mcg/dL.

What does a ceruloplasmin blood test check for?

Ceruloplasmin testing is used primarily, along with blood and/or urine copper tests, to help diagnose Wilson disease, a rare inherited disorder associated with excess storage of copper in the eyes, liver, brain, and other organs, and with decreased levels of ceruloplasmin.

What is ceruloplasmin in blood test results?

Ceruloplasmin is a copper-containing enzyme that plays a role in the body’s iron metabolism. This test measures the amount of ceruloplasmin in the blood.

Is ceruloplasmin low in copper deficiency?

When urine and serum concentrations of both copper and ceruloplasmin are low, then the patient is simply suffering from a copper deficiency. Anything interfering with the body’s ability to metabolize copper may also affect the serum ceruloplasmin levels.

What does a ceruloplasmin blood test tell you?

A ceruloplasmin test can determine the levels of ceruloplasmin in your body. The test is most often used to diagnose Wilson’s disease, a rare genetic disorder. Wilson’s disease causes too much copper to collect in the liver, the brain, and other body tissues and organs. It’s also known as hepatolenticular degeneration.

What is considered a low copper level?

The normal range for total copper in the blood is 85 to 180 micrograms per deciliter (mcg/dL). A low amount of copper could mean that you have: Kidney disease.

What are normal levels of ceruloplasmin in blood?

Greater-than-normal ceruloplasmin levels may indicate or be noticed in: Normal blood concentration of ceruloplasmin in humans is 20–50 mg/dL. Reference ranges for blood tests, comparing blood content of ceruloplasmin (shown in gray) with other constituents.

How are ceruloplasmin levels reduced in healthy adults?

A combination of caloric restriction and exercise reduced ceruloplasmin levels after 6 months in non-smoking, healthy, overweight adults (ages 25 to 50 years) [ 67 ]. For diseases that are associated with higher ceruloplasmin levels, treatment of the disease can sometimes reduce ceruloplasmin levels.

What is ceruloplasmin?

Ceruloplasmin is a protein made in your liver. Ceruloplasmin stores and carries the mineral copper around your body. Ceruloplasmin carries 65% to 90% of the copper found in blood. Copper is vital to many processes in your body. These include building strong bones and making melanin. But having too much copper in your body can be toxic.

How do you take a ceruloplasmin test?

Blood ceruloplasmin tests are commonly taken along with a urine copper level test. Blood sample. A healthcare professional will take a blood sample from you. That involves puncturing a vein, usually in the arm, with a needle and withdrawing blood.