What are the fates of pyruvate in glycolysis?

Pyruvate is the end product of glycolysis. Two molecules of pyruvate are produced by the partial oxidation of glucose. The three main ways by which pyruvate is utilised by cells are aerobic respiration, lactic acid fermentation and alcoholic fermentation (anaerobic respiration).

Where does fate of pyruvate occur?

The fate of pyruvate depends on the availability of oxygen. If oxygen is available, then pyruvate is shuttled into the mitochondria and continues through several more biochemical reactions called the “Citric Acid Cycle.” This is called aerobic metabolism.

Where does glycolysis take place?

the cytoplasm
Glycolysis takes place in the cytoplasm. Within the mitochondrion, the citric acid cycle occurs in the mitochondrial matrix, and oxidative metabolism occurs at the internal folded mitochondrial membranes (cristae).

Where is pyruvate in glycolysis?

Pyruvate is produced by glycolysis in the cytoplasm, but pyruvate oxidation takes place in the mitochondrial matrix (in eukaryotes). So, before the chemical reactions can begin, pyruvate must enter the mitochondrion, crossing its inner membrane and arriving at the matrix.

What are the 4 fates of pyruvate?


  • Acetyl CoA: substrate for citric acid cycle and fatty acid synthesis.
  • Oxaloacetate: intermediate in CAC and substrate for gluconeogenesis.
  • Lactate: produced by eukaryotes in absence of oxygen.
  • Ethanol: produced by yeast and some bacteria (including intestinal flora) in absence of oxygen.

What’s the fate of pyruvate?

Pyruvate are mainly converted into ethanol, lactic acid, or carbon dioxide (Figure 1). enzyme pyruvate dehydrogenase complex (PDC) because former cannot enter the TCA cycle (Figure-2).

What is the fate of glycolysis?

The final product of glycolysis is pyruvate in aerobic settings and lactate in anaerobic conditions. Pyruvate enters the Krebs cycle for further energy production.

Does glycolysis occur inside or outside the mitochondria?

No, glycolysis occurs in the cytosol. Glycolysis is the process by which glucose is partially oxidised to form pyruvate, which is transported to mitochondria for further oxidation.

Where does glycolysis take place in prokaryotic cells?

Glycolysis takes place in the cytoplasm of both prokaryotic and eukaryotic cells. Glucose enters heterotrophic cells in two ways. One method is through secondary active transport in which the transport takes place against the glucose concentration gradient.

What is pyruvate glycolysis?

Pyruvate is the end-product of glycolysis, is derived from additional sources in the cellular cytoplasm, and is ultimately destined for transport into mitochondria as a master fuel input undergirding citric acid cycle carbon flux.

What happens during glycolysis?

During glycolysis, glucose ultimately breaks down into pyruvate and energy; a total of 2 ATP is derived in the process (Glucose + 2 NAD+ + 2 ADP + 2 Pi –> 2 Pyruvate + 2 NADH + 2 H+ + 2 ATP + 2 H2O). The hydroxyl groups allow for phosphorylation. The specific form of glucose used in glycolysis is glucose 6-phosphate.

Which is not among the possible fates of pyruvate after glycolysis?

Ethanol fermentation (the fermentation of pyruvate into acetaldehyde and then ethanol to replenish NAD+ levels) does not occur in eukaryotes.