How many fanconi anemia genes?

Fanconi anemia is an inherited disease caused by changes (mutations) in certain genes, known as FA genes. Experts have found 23 different FA genes. The disease occurs when there is a change (mutation) in one of these 23 genes.

How many FA genes are there?

FA is a genetic disorder caused by inherited mutations (discrete changes in genetic code) in a group of genes (genetic blueprints) for proteins. We have about 20 FA genes, but not all of them are affected when genes mutate. FA genes protect us from DNA damage that happens throughout life.

What is the best treatment for Fanconi?

Stem cell transplant is the current standard treatment for Fanconi anemia that is causing major bone marrow failure. Growth factors—are natural or man-made growth substances that help the body make more red and white blood cells.

What are the symptoms of Fanconi syndrome in dogs?

The symptoms of Fanconi syndrome usually make their first appearance in dogs between the ages of four and seven, although they can develop as early as 11 months of age. They typically include frequent urination, excessive thirst, low energy, poor muscle tone, and weight loss despite normal eating habits.

Is Fanconi syndrome curable?

Fanconi syndrome cannot be cured, but it can be controlled with proper treatment. Effective treatment can keep the damage to bones and kidney tissue from getting worse and in some cases correct it. The high acid level of the blood (acidosis) may be neutralized by drinking sodium bicarbonate.

What causes Fanconi?

Cystinosis is the most common cause of Fanconi syndrome in children. Other causes in children include: Exposure to heavy metals such as lead, mercury, or cadmium. Lowe syndrome, a rare genetic disorder of the eyes, brain, and kidneys.

Is Fanconi syndrome fatal in dogs?

Some dogs remain stable for years, but others may develop rapidly progressing kidney failure over just a few months. Most dogs with Fanconi syndrome ultimately die of end-stage kidney failure.