Can PKU cause anxiety?

People with PKU, especially those with Phe levels above the recommended range, often report feeling depressed, anxious, and agitated. Medical studies have shown that people with PKU are more likely to be depressed and anxious, and to suffer from phobias and reduced positive emotions and achievement.

Are there any therapies for PKU?

The Food and Drug Administration (FDA) approved the drug sapropterin (Kuvan) for the treatment of PKU . The drug may be used in combination with a PKU diet.

Can PKU brain damage be reversed?

Although the severe cognitive impairment associated with untreated PKU can in many cases be partially reversed with die- tary treatment, prompt initiation of treatment following newborn metabolic screening is essential for optimal development and the prevention of disability.

How does PKU affect a person emotionally?

As children and adolescents, patients with PKU may have learning difficulties, school problems, decreased motivation, less social competence, irritability, hyperactivity, mood disorders, and poor self esteem.

What is the life expectancy of a person with phenylketonuria?

PKU does not shorten life expectancy, with or without treatment. Newborn screening for PKU is required in all 50 states. PKU is usually identified by newborn screening. A child’s outlook is very good if she strictly follows the diet.

Can PKU cause schizophrenia?

The postulated pathogenesis of brain dysfunction in PKU could overlap that of schizophrenia. Our results suggest that treatment of phenylalanine imbalance may have a therapeutic potential in schizophrenia.

Why does PKU cause brain damage?

People with PKU cannot break down the amino acid phenylalanine, which then builds up in their blood and brain. This can lead to brain damage.

Can PKU cause ADHD?

Individuals with PKU and ADHD seem to have low levels of DA in common, causing the hypodopaminergic state found in both disorders to be a possible link between these two conditions, and individuals with PKU could have a greater predisposition to the development of ADHD.

Is PKU considered a disability?

The Social Security Administration (SSA) addresses Phenylketonuria under Section 10.00 of the Blue Book, Multiple Body Systems. Phenylketonuria is specifically listed as an impairment that can cause interruption of normal body function and development under Section 10.00, Paragraph C.

Why does PKU cause mental retardation?

The faulty protein allows dangerously high levels of phenylalanine to accumulate in the brain, poisoning the cells. If a person with PKU consumes too much phenylalanine, the build-up can cause mental retardation.