What is the mechanism of action of pantoprazole?

Pantoprazole exerts its stomach acid-suppressing effects by preventing the final step in gastric acid production by covalently binding to sulfhydryl groups of cysteines found on the (H+, K+)-ATPase enzyme at the secretory surface of gastric parietal cell.

What is the pharmacokinetics of pantoprazole?

Pantoprazole shows linear pharmacokinetics after both i.v. and oral administration. Pantoprazole is extensively metabolized in the liver, has a total serum clearance of 0.1 l/h/kg, a serum elimination halflife of about 1.1 h, and an apparent volume of distribution of 0.15 l/kg.

What is the action of proton pump inhibitors?

Proton pump inhibitors (PPIs) effectively block gastric acid secretion by irreversibly binding to and inhibiting the hydrogen-potassium ATPase pump that resides on the luminal surface of the parietal cell membrane.

What are the reactions to pantoprazole?

Though it’s rare, pantoprazole can cause an allergic reaction. Symptoms may include rash, swelling, or breathing problems….Allergy warning

  • nausea or vomiting.
  • fever.
  • rash.
  • confusion.
  • blood in your urine.
  • bloating.
  • elevated blood pressure.

What is the mechanism of action of omeprazole?

Mechanism of action It suppresses stomach acid secretion by specific inhibition of the H+/K+-ATPase system found at the secretory surface of gastric parietal cells. Because this enzyme system is regarded as the acid (proton, or H+) pump within the gastric mucosa, omeprazole inhibits the final step of acid production.

What is the difference between pantoprazole and omeprazole?

While omeprazole is FDA-approved to treat H. pylori in combination with other drugs, pantoprazole is used off-label for this infection. Other off-label uses for both drugs include Barrett’s esophagus and ulcers that stem from the use of nonsteroidal anti-inflammatory drugs (NSAIDs).

Is pantoprazole a vasodilator?

Pantoprazole reduces vascular relaxation in-vitro and ex-vivo and interferes with blood coagulation in an animal model.

How do proton pumps contribute to membrane potential?

The proton pump uses energy from ATP to pump hydrogen ions (H+) out of the cell. The pump contributes to a voltage called membrane potential. Proton pumping makes the inside of a plant cell negative.

How do proton pump inhibitors affect acid in the stomach?

How Do Proton Pump Inhibitors Work? PPIs work by blocking and reducing the production of stomach acid. This gives any damaged esophageal tissue time to heal. PPIs also help prevent heartburn, the burning sensation that often accompanies GERD.

Why pantoprazole is used?

Pantoprazole is used to allow the esophagus to heal and prevent further damage to the esophagus in adults with GERD. It is also used to treat conditions where the stomach produces too much acid, such as Zollinger-Ellison syndrome in adults. Pantoprazole is in a class of medications called proton-pump inhibitors.

What is difference between omeprazole and pantoprazole?