What pathway is HMG-CoA reductase?

the mevalonate pathway
HMG-CoA Reductase (or 3-hydroxy-3-methyl-glutaryl-CoA reductase or HMGR) is the rate-controlling enzyme of the mevalonate pathway, responsible for cholesterol and other isoprenoid biosynthesis. HMGR is a transmembrane protein, containing 8 domains, that is anchored in the membrane of the endoplasmic reticulum.

Where do statins inhibit HMG-CoA reductase?

Statins competitively inhibit the HMG-CoA reductase enzyme. Statins bind to the active site of the enzyme and change its structure. As the structure of the enzyme is changed, it cannot bind with the receptor, thus its activity is reduced.

Where is HMG-CoA reductase located in the cell?

the endoplasmic reticulum
HMG-CoA reductase is anchored in the membrane of the endoplasmic reticulum, and was long regarded as having seven transmembrane domains, with the active site located in a long carboxyl terminal domain in the cytosol.

What pathways is HMG-CoA involved?

β-Hydroxy β-methylglutaryl-CoA (HMG-CoA), also known as 3-hydroxy-3-methylglutaryl coenzyme A, is an intermediate in the mevalonate and ketogenesis pathways.

What is the mechanism of action of HMG-CoA reductase inhibitors?

Introduction. Also known as statins, HMG-CoA reductase inhibitors work by inhibiting the synthesis of cholesterol in the liver by the enzyme HMG-CoA reductase.

Where is HMG CoA synthase located?

The cytosolic or cholesterogenic isozyme provides the HMG-CoA destined for isoprenoid biogenesis, a process that occurs in the cytosol. Linkage analysis revealed that the mouse genes that encode the cytosolic and mitochondrial HMG-CoA synthases are located on different chromosomes.

How do statins inhibit cholesterol synthesis?

In vitro statins act indeed as competitive inhibitors of HMG-CoA reductase (HMGCR), the rate-limiting enzyme of cholesterol synthesis. When statins are bound to HMGCR, they block the access of the natural substrate HMG-CoA to the catalytic site and thereby interfere with cholesterol synthesis (4).

Which drug belongs to the class HMG-CoA reductase inhibitors quizlet?

Simvastatin, or Zocor, belongs to the HMG-CoA reductase inhibitor class of cholesterol lowering medications.

Where is HMG-CoA synthase located?

What is HMG-CoA reductase inhibitor?

Listen to pronunciation. (HMG-koh-A ree-DUK-tays in-HIH-bih-ter) A substance that blocks an enzyme needed by the body to make cholesterol and lowers the amount of cholesterol in the blood. HMG-CoA reductase inhibitor drugs are called statins.

Which of the following is HMG-CoA reductase inhibitor *?

Pitavastatin (Livalo) HMG-CoA reductase inhibitor (statin) indicated for primary or mixed hyperlipidemia in adults.

What is HMG-CoA inhibitor?