What is zaroxolyn prescribed for?

This drug is used to treat high blood pressure. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. This medication also reduces swelling/fluid retention (edema) which can result from conditions such as congestive heart failure or kidney disease.

What is the indication of metolazone?

Metolazone tablets are indicated for the treatment of salt and water retention including: edema accompanying congestive heart failure; edema accompanying renal diseases, including the nephrotic syndrome and states of diminished renal function.

What is metolazone used to treat?

Metolazone is used to treat fluid retention (edema) and swelling that is caused by congestive heart failure, kidney disease, or other medical conditions . Metolazone is also used alone or together with other medicines to treat high blood pressure (hypertension).

What is the difference between Lasix and zaroxolyn?

Lasix works by blocking the absorption of salt and water from the filtered fluid in the kidney tubules, causing a marked increase in urine output (diuresis). Zaroxolyn is a diuretic (“water pill”) used in the treatment of high blood pressure and fluid accumulation.

Can you take Zaroxolyn and Lasix together?

You may need dose adjustments or special tests in order to safely take both medications together. This combination may lower levels of certain minerals in your body such as potassium, magnesium, and sodium.

Why is metolazone given before furosemide?

Many physicians dose metolazone 30 minutes prior to dosing the loop diuretic to ensure the distal Na-Cl channel is already blocked when the increased sodium reaches the DCT.

Why do you give metolazone before furosemide?

Even at low doses metolazone significantly potentiates the diuretic effects of furosemide and therefore simplifies the treatment of fluid retention. High doses of furosemide can be avoided in many cases, a factor of particular advantage in ambulatory long term therapy and in patients with decreased kidney function.

Is Zaroxolyn potassium sparing?

Metolazone can reduce blood potassium and magnesium levels. This is especially true in patients who also are taking “loop” diuretics such as furosemide (Lasix), bumetanide (Bumex), and torsemide (Demadex ).

Does metolazone lower blood pressure?

Metolazone is a thiazide diuretic (water pill). It reduces the amount of water in the body by increasing the flow of urine, which helps to lower blood pressure .

Can Lasix and Zaroxolyn be given together?

Why do you give metolazone before Lasix?

Does metolazone cause hyponatremia?

Metolazone was strongly associated with hyponatremia, hypokalemia, and worsening renal function (P<0.0001 for all) with minimal effect attenuation following covariate and propensity adjustment.