What is the function of muscle-specific tyrosine kinase?

MuSK (for Muscle-Specific Kinase) is a receptor tyrosine kinase required for the formation and maintenance of the neuromuscular junction. It is activated by a nerve-derived proteoglycan called agrin.

What is the function of MuSK?

Muscle-specific kinase (MuSK) is a single-pass transmembrane protein that has a critical role in signaling between motor neurons and skeletal muscle.

What is muscle kinase?

What is a creatine kinase (CK) test? This test measures the amount of creatine kinase (CK) in the blood. CK is a type of protein, known as an enzyme. It is mostly found in your skeletal muscles and heart, with lesser amounts in the brain. Skeletal muscles are the muscles attached to your skeleton.

What is anti MuSK AB?

An anti-MuSK antibody test is used to help diagnose myasthenia gravis (MG) in people with signs and symptoms associated with MG but who test negative for AChR antibodies. Testing is used to distinguish MG from other conditions that may cause similar symptoms, such as chronic muscle fatigue and weakness.

What is MuSK in myasthenia gravis?

Muscle-specific tyrosine kinase (MuSK) myasthenia gravis (MG) is a rare, frequently more severe, subtype of MG with different pathogenesis, and peculiar clinical features. The prevalence varies among countries and ethnic groups, affecting 5–8% of all MG patients.

What are the types of myasthenia gravis?

There are two clinical forms of myasthenia gravis: ocular and generalized. In ocular myasthenia gravis, muscle weakness often first appears in the muscles of the eyelids and other muscles that control movement of the eye (extraocular muscle).

What is MuSK gene?

MUSK Gene – Muscle Associated Receptor Tyrosine Kinase This gene encodes a muscle-specific tyrosine kinase receptor. The encoded protein may play a role in clustering of the acetylcholine receptor in the postsynaptic neuromuscular junction.

Is creatine kinase A transferase?

Creatine Kinase (C0010287) A transferase that catalyzes formation of PHOSPHOCREATINE from ATP + CREATINE. The reaction stores ATP energy as phosphocreatine.

What does MuSK positive mean?

Diagnostic Approach A positive result for MuSK-Ab, sustained by clinical evidences, supports the diagnosis of MuSK-MG. Detection of MuSK-Ab is usually a second step for AChR-Abs-negative patients or individuals positive for AChR-Ab who do not respond to treatment.