What is midazolam injection used for?

Midazolam injection is used to produce sleepiness or drowsiness and relieve anxiety before surgery or certain procedures.

What is the mechanism of action of midazolam?

The mechanism of action of midazolam indirect and is related to GABA accumulation and its affinity to the benzodiazepine receptors. Two separate receptors for GABA and benzodiazepine couple to a common chloride channel. It increases the frequency of chloride channel opening.

What are the properties of midazolam?

Pharmacodynamic properties of midazolam and its metabolites, which are similar to those of other benzodiazepine drugs, include sedative, anxiolytic, amnestic, muscle relaxant, as well as hypnotic activities. Benzodiazepines enhance the inhibitory action of the amino acid neurotransmitter gamma-aminobutyric acid (GABA).

Does midazolam lower blood pressure?

Midazolam does not affect BP or HR.

What class of drug is midazolam?

Midazolam is in a class of medications called benzodiazepines. It works by slowing activity in the brain to allow relaxation and sleep.

What type of anesthesia is midazolam?

Midazolam is a good premedicant for general or regional anesthesia. Its greatest use will probably be for conscious sedation during surgical or diagnostic procedures performed under local or regional anesthesia.

What is the chemical name for midazolam?

Midazolam

Clinical data
IUPAC name 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine
CAS Number 59467-70-8
PubChem CID 4192
IUPHAR/BPS 3342

How does midazolam work GABA?

Midazolam activates the GABAA receptor by augmenting the binding of GABA to the receptor and midazolam directly activates the GABAA receptor at a high concentration. The γ2 subunit is essential for binding benzodiazepine to the GABAA receptor [10].

Where do you inject midazolam?

This medication is given by slow injection into a vein or muscle as directed by your doctor. It is usually given by a health care professional.