What is Leucodepleted red blood cells?

One of the strategies commonly used to prevent posttransfusion complications is leukodepletion, that is, a process by which the white blood cells (WBCs) are intentionally reduced by almost 99.99% to PRBC.

Why is leukocyte reduced blood transfusion recommended?

Conclusions: The use of leukocyte-reduced blood components significantly diminishes or prevents many of the adverse transfusion reactions associated with donor white blood cells.

How do you Leukoreduce blood?

Leukoreduction can be performed by filtration prior to component storage (prestorage leukoreduction) or during the transfusion (bedside filtration). For apheresis-derived platelets, leukoreduction is often performed by cell separation during the apheresis collection.

How do you irradiate blood products?

Irradiation of blood products is undertaken using a dedicated blood irradiator located onsite with a long half-life gamma emitting source. Irradiation of blood products will take a further 4 – 5 minutes to provide.

What is Leucodepleted blood used for?

Indications for leucodepleted transfusion Reduction of CMV transmission e.g. in patients awaiting organ transplantation. Reduction in the risk of Yersinia enterocolitica contamination of RBC. Possible reduction of Prion Disease. Reduction in the incidence of transfusion associated GVHD (TA-GVHD).

Why do we Leukoreduce blood products?

Leukoreduced blood and components are used to decrease the incidence of febrile transfusion reactions: to decrease the risk of cytomegalovirus (CMV) transmission to CMV negative immunocompromised or pregnant recipients, and to decrease sensitization to human leukocyte antigens (HLA) (important for transplant patients …

When is leukoreduction done?

When should you irradiate blood?

As described in the Technical Manual (20th Edition) and Circular of Information (October 2017), cellular blood components are irradiated prior to transfusion to prevent the proliferation of viable T lymphocytes which are the immediate cause of Transfusion Associated-Graft Versus Host Disease (TA-GVHD).

Why do they irradiate blood?

Irradiating blood components prevents the donor white cells replicating and mounting an immune response against a vulnerable patient causing transfusion-associated-graft-versus-host disease (TA-GvHD). Who should you inform if your patient requires irradiated blood components?

Is FFP and platelets the same?

One unit of FFP has a concentration of coagulation factors similar to that of 4 to 5 units of platelet concentrates, 1 apheresis unit of platelets, and 1 unit of fresh whole blood; 1 mL/kg of FFP raises most factor levels by approximately 1%.

Why do we irradiate blood?

Who needs Leukoreduced blood?

Generally accepted indications for leukoreduction of blood products include: (1) reduction of HLA alloimmunization risk in patients who require long term platelet support, or for potential organ transplant recipients; (2) reduction of CMV transmission in at-risk patients; and (3) reduction of the rate of recurrent …