What is Hyper-CVAD protocol?

An abbreviation for a chemotherapy combination used to treat some types of acute lymphoblastic leukemia (ALL) and non-Hodgkin lymphoma (NHL). Hyper-CVAD regimen includes the drugs cyclophosphamide, vincristine sulfate, doxorubicin hydrochloride (Adriamycin), and dexamethasone.

What is in Hyper-CVAD?

Hyper-CVAD includes the drugs cyclophosphamide, vincristine sulfate, doxorubicin hydrochloride (Adriamycin), and dexamethasone. It also includes the drugs methotrexate and cytarabine.

How effective is Hyper-CVAD?

Patients treated with the hyper-CVAD regimen (hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone alternating with methotrexate and cytarabine) are reported to have up to a 92% complete remission (CR) rate and 38% 5-year overall survival (OS) rate in clinical trials.

What is Hyper-CVAD Part B?

HyperCVAD (Part B) is a Chemotherapy Regimen for Acute Lymphoid Leukemia (ALL)

What is modified hyper-CVAD?

The modified hyper-CVAD regimen is a combination of chemotherapy drugs including cyclophosphamide, vincristine, Adriamycin, dexamethasone and pegylated asparaginase given together for one “course” of treatment.

What is PH negative all?

Older adults with Philadelphia chromosome negative (Ph-),-B-cell acute lymphoblastic leukemia (ALL) have the highest rates of treatment failure and treatment complications with current therapy, and, thus, there is no standard treatment for these patients.

What cyclophosphamide is used for?

Cyclophosphamide is used to treat cancer of the ovaries, breast, blood and lymph system, and nerves (mainly in children). Cyclophosphamide is also used for retinoblastoma (a type of eye cancer mainly in children), multiple myeloma (cancer in the bone marrow), and mycosis fungoides (tumors on the skin).

What is modified Hyper-CVAD?

How often is Hyper-CVAD given?

HyperCVAD Part A is alternated with HyperCVAD Part B every 21 days. This sometimes takes longer if waiting for normal blood counts recover after the previous cycle. When both Part A and Part B are completed, this is known as one Cycle.

How is Hyper-CVAD administered?

Hyper-CVAD is given as hyperfractionated therapy, in which the total daily dose is divided into smaller doses and given more than once a day. This combination may also be used with other drugs or treatments or to treat other types of cancer.