What are the requirements for designing a bioreactor?

The material used for the construction of a bioreactor must have the following important properties:

  • It should not be corrosive.
  • It should not add any toxic substances to the fermentation media.
  • It should tolerate the steam sterilization process.
  • It should be able to tolerate high pressure and resist pH changes.

How will you design and construct a fermenter?

The vessel should be well equipped to maintain aseptic conditions inside it for a number of days. Aeration and agitation are important for the production of biological metabolites. However, controlled agitation is required to prevent any damage to the cells.

What should be the basic points of consideration while designing a fermenter?

The basic points of consideration while designing a fermenter:

  • Productivity and yield.
  • Fermenter operability and reliability.
  • Product purification.
  • Water management.
  • Energy requirements.
  • Waste treatment.

Which reactor is used for fermentation?

As of now stirred tank bioreactor is preferred in industry for fermenting purpose. Generally, tubular towers (cylindrical, cylindro-conical) are used for ethanol and beer fermentation. Ethanol fermentation have been carried out even in STRs and huge column reactors.

What is batch fermentation?

Batch fermentation is the simplest mode of fermentation, made up of a mechanically stirred vessel with other accessories such as a gas sparger and a heating/cooling jacket. The substrates and supplementary nutrients are charged in the vessel, autoclaved at 120°C, cooled to 35–37°C, and inoculated with bacteria.

How do you add oxygen to a fermentation reactor?

Sterile air (or possibly oxygen) for aerobic fermentation is introduced by means of a bubble sparger located below the lowest of the impeller. Cooling (heating) can take place through the reactor wall or by the use of internal coils [2].

Is there an industrial scale batch stirred fermenter design for ethanol production?

Then the industrial scale batch stirred fermenter design for ethanol production with cells Saccharomyces cerevisiaeis the matter of our concern. Only engineering aspects are taken into account in order to properly model the bioreactor and allow scale-up [2].

Can microbial phenomena improve the alcoholic fermentation technology of Bath stirred bioreactor?

Conclusion In conclusion, the present investigation has demonstrated the importance of some fermentation parameters (microbial phenomena) in improving the alcoholic fermentation technology [23] of bath stirred industrial scale bioreactor for ethanol production with Saccharomyces cerevisiae.

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