Is vinorelbine effective?

Weekly vinorelbine is an effective palliative regimen after failure with anthracyclines and taxanes in metastatic breast carcinoma. Cancer.

How does vinorelbine work?

Vinorelbine is used alone and in combination with other medications to treat non-small cell lung cancer (NSCLC) that has spread to nearby tissues or to other parts of the body. Vinorelbine is in a class of medications called vinca alkaloids. It works by slowing or stopping the growth of cancer cells in your body.

Is vinorelbine well tolerated?

Abstract. BACKGROUND: Vinorelbine, a semisynthetic vinca alkaloid, represents a well-tolerated treatment for elderly patients with advanced non-small-cell lung cancer (NSCLC).

What are the side effects of vinorelbine?

Nausea, vomiting, fatigue, constipation, diarrhea, dizziness, muscle aches, joint pain, or irritation at the injection site may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Temporary hair loss may occur. Normal hair growth should return after treatment has ended.

How long does vinorelbine stay in your system?

Both men and women having vinorelbine should use contraception for at least three months after having their last dose of vinorelbine. Speak to your treatment team about the most suitable method of contraception for you and how long to use it for after the last dose of vinorelbine.

How do you administer vinorelbine?

Administration Administer diluted NAVELBINE over 6 to 10 minutes into the side port of a free-flowing intravenous line followed by flushing with at least 75 to 125 mL of one of the solutions. NAVELBINE must only be administered intravenously.

How effective is Navelbine?

A phase 2 clinical trial that is studying the effectiveness of navelbine (vinorelbine) as a single-agent first-line treatment is showing a partial response rate of 24%, a stable disease rate of 55% with 21% of patients experiencing disease progression during treatment.

Does vinorelbine cause neuropathy?

Mild to moderate peripheral neuropathy occurs in 7% to 31% of patients treated with vinorelbine, whereas severe toxicity has been reported in only a few cases and is particularly associated with concomitant or previous treatment with paclitaxel.

How often is vinorelbine given?

Consider blood transfusion if patient symptomatic of anaemia or has a haemoglobin of less than 8g/dL. The initial dose of oral vinorelbine is 60mg/m2 once a week for the first three weeks of treatment. The neutrophil and platelet count should be checked once a week for these three weeks.

Is vinorelbine a chemo drug?

Vinorelbine is a type of chemotherapy. You might have it as a treatment for: advanced breast cancer. Non small cell lung cancer.