Is indole-3-carbinol a estrogen blocker?

Indole-3-carbinol, derived from Cruciferous vegetables is an estrogen receptor antagonist considered a preventive agent that is naturally present in diet.

What are the benefits of indole-3-carbinol?

There is interest in indole-3-carbinol for cancer prevention, particularly breast, cervical, and colon cancer, because diets with higher amounts of fruits and vegetables are linked to a decreased risk of these cancers. Indole-3-carbinol is present in several vegetables and might help protect against cancer.

Is indole-3-carbinol carcinogenic?

Some animal studies suggest that I3C is both an inhibitor and promoter of carcinogenesis with strong induction of placental glutathione S-transferase foci in the liver (57), and modulatory activity that included apoptotic inhibition in colon tumors (55).

Can indole-3-carbinol help lose weight?

These findings suggest that I3C has a potential benefit in preventing obesity and metabolic disorders, and the action for I3C in vivo may involve multiple mechanisms including decreased adipogenesis and inflammation, along with activated thermogenesis.

Which is better DIM or I3C?

In summary, we have known for a long time that I3C is partially responsible for many of the beneficial effects of consuming cruciferous vegetables. I3C breaks down to many different active metabolites, but DIM appears to be the most stable, and the most measurable, making it easier to isolate.

Is DIM or indole-3-carbinol better?

Can DIM cause kidney problems?

Most notably, no effects were seen in DIM-metabolized organs such as kidney and liver. All of the tissues and organs showed a normal structure and appearance.

Is indole-3-carbinol the same as DIM?

I3C is relatively unstable – meaning it quickly converts to DIM and other substances after it’s in your stomach. DIM, on the other hand, is quite stable. Whether converted from I3C or taken as a supplement, DIM progresses beyond your stomach as the active molecule in your body.