What is Methysergide used for?

What is Methysergide used for?

Methysergide is used for prevention of intractable migraine and cluster headache. It is no longer available in the US. It is an ergotamine, and its mechanism for migraine prevention is believed to be mediated through antagonism of the 5-HT2B receptor.

What is chemical name of Methysergide?

Methysergide

What kind of drug is Sansert?

Sansert (methysergide maleate) is an anti-migraine medication used to prevent vascular headaches (e.g., migraines) and to reduce their severity. The brand name Sansert is discontinued, but generic versions may be available. Common side effects of Sansert (methysergide maleate) include: nausea.

Is Methysergide a serotonin antagonist?

Methysergide is a semisynthetic ergot alkaloid ergometrine derivative, introduced in pharmacotherapy for migraine prophylaxis as a specific serotonin (5HT) receptor antagonist. Methysergide is not just a 5HT2 antagonist, it is also a 5HT1 agonist. Open and controlled studies attest to methysergide’s efficacy.

What is the other name for methyldopa?

Aldomet (methyldopa) is an antihypertensive drug used to treat hypertension (high blood pressure). The brand name Aldomet is discontinued in the U.S. Generic forms may be available.

What is amiodarone used for?

Amiodarone is used to treat life-threatening heart rhythm problems called ventricular arrhythmias. This medicine is used in patients who have already been treated with other medicines that did not work well.

Which of the following adverse effects is characteristically associated with Methysergide?

It has a known side effect, retroperitoneal fibrosis/retropulmonary fibrosis, which is severe, although uncommon. This side effect has been estimated to occur in 1/5000 patients. In addition, there is an increased risk of left-sided cardiac valve dysfunction.

Are triptans serotonin agonists?

The triptans are serotonin agonists with high affinity for the 5-HT1B and 5-HT1D receptors which are found on smooth-muscle cells of blood vessels. Simulation of the 5-HT1D receptor results in constriction of intracranial blood vessels.

What class of drug is methyldopa?

Methyldopa belongs to the general class of medicines called antihypertensives. It is used to treat high blood pressure (hypertension). High blood pressure adds to the work load of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly.