What is the pathogenesis of RA?

Rheumatoid arthritis (RA) is an autoimmune systemic disease that primarily affects joints. Etiology and the pathogenesis of RA are complex, involving many types of cells, among others macrophages, T and B cells, fibro- blasts, chondrocytes and dendritic cells.

Which step involved in the development of pathogenesis of rheumatoid arthritis?

Phase I – Interaction between genetic and environmental risk factors of RA. Phase II – Production of RA autoantibodies, such as rheumatoid factor (RF) and anti–cyclic citrullinated peptide (anti-CCP) Phase III – Development of arthralgia or joint stiffness without any clinical evidence of arthritis.

What is rheumatoid arthritis explain its symptoms and pathogenesis?

Rheumatoid arthritis (RA) is a chronic symmetric polyarticular joint disease that primarily affects the small joints of the hands and feet. The inflammatory process is characterized by infiltration of inflammatory cells into the joints, leading to proliferation of synoviocytes and destruction of cartilage and bone.

How is rheumatoid arthritis related to pathophysiology?

Although the pathophysiology of RA is not completely understood, the process generally involves dysregulated inflammation, with antigen presentation, T-cell activation, and autoantibody production all serving as mediators in the inflammatory process.

What are the pathological changes of rheumatoid arthritis?

RA primarily affects the lining of the synovial joints and can cause progressive disability, premature death, and socioeconomic burdens. The clinical manifestations of symmetrical joint involvement include arthralgia, swelling, redness, and even limiting the range of motion.

What is Stage 3 rheumatoid arthritis?

Stage 3. People with stage 3 RA, or severe RA, often experience much more severe pain and more frequent joint swelling and associated symptoms than those typical of stage 1 or stage 2. In stage 3 RA, inflammation becomes so severe that it destroys joint bones and cartilage.

What are the pathologies changes of rheumatoid arthritis?

What is the basic pathology of rheumatoid arthritis group of answer choices?

Rheumatoid arthritis is characterized by the presence of autoantibodies known as rheumatoid factors (RF) and anti-citrullinated peptide antibodies (ACPA, which includes the anti-cyclic citrullinated peptide antibody or anti-CCP). Rheumatoid factors have been long recognized as a feature of many patients with RA.

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