Which drug is histamine antagonist?

H2 blockers are a group of medicines that reduce the amount of acid produced by the cells in the lining of the stomach. They are also called ‘histamine H2-receptor antagonists’ but are commonly called H2 blockers. They include cimetidine, famotidine, nizatidine and ranitidine, and have various different brand names.

What drugs are H4 blockers?

H4R ligands In clinical practice, currently there are no drugs that block the histamine H4 receptor activity selectively. The first potent and selective H4R antagonist, JNJ7777120, was described in 2003 along with another selective H4R antagonist that is a 7-NH2 substituted indolyl-piperazine derivative [165].

What type of drug is H1-receptor antagonist?

Abstract. Histamine is an important neurotransmitter. Old (first-generation) H1-receptor antagonists such as chlorpheniramine, diphenhydramine, or triprolidine produce histamine blockade at H1-receptors in the central nervous system (CNS) and frequently cause somnolence or other CNS adverse effects.

What do h3 receptors do?

H3 receptors function as presynaptic autoreceptors on histamine-containing neurons. The diverse expression of H3 receptors throughout the cortex and subcortex indicates its ability to modulate the release of a large number of neurotransmitters. H3 receptors are thought to play a part in the control of satiety.

What do histamine antagonists do?

Descriptions. Histamine H2-receptor antagonists, also known as H2-blockers, are used to treat duodenal ulcers and prevent their return. They are also used to treat gastric ulcers and for some conditions, such as Zollinger-Ellison disease, in which the stomach produces too much acid.

What is an H4 antihistamine?

Histamine H4 receptor antagonists may have clinical potential in treatment of neuroimmune disorders and potentially also neurodegenerative disorders where inflammation and immune mechanisms play crucial roles. So far, however, these drugs have been tested mostly for immune and dermatological conditions.

What is H4 receptor antagonist?

A selective H4R antagonist inhibited histamine-induced pruritus in health volunteers and reduced pruritus in patients with atopic dermatitis. The history to date of the H4R provides an excellent example of the deorphanization of a novel receptor and the translation of this into clinical efficacy in humans.

What are brand names of H1 antihistamines?

Brands include AllerMax, Altaryl Children’s Allergy, Banophen, Benadryl, Diphenhist, Dormin, Genahist, Miles Nervine, Nytol, Siladryl, Sleep-eze 3, Sleepwell 2-nite, and Sominex.

Is there an H3 antihistamine?

Consequently, unlike the H1 antagonist antihistamines which are sedating, H3 antagonists have stimulant and nootropic effects, and are being researched as potential drugs for the treatment of neurodegenerative conditions such as Alzheimer’s disease.

What is H3 antihistamine?

Histamine H3 receptor (H3R) antagonists/inverse agonists have revealed potential to treat diverse disease states of the central nervous system (CNS) including Alzheimer’s disease (AD), attention-deficit hyperactivity syndrome (ADHD), schizophrenia, obesity, pain, epilepsy, narcolepsy, substance abuse, etc.