Is cyclosporine soluble in water?

The solubility of cyclosporine A in various solvents (according to Novartis and [57]). CsA is generally soluble in organic solvents such as methanol, ethanol, acetone, ether and chloroform (Tab. 1). It is also slightly soluble in saturated hydrocarbons [1] and in water.

How do you dissolve cyclosporine?

Cyclosporin A is supplied as a solid. A stock solution may be made by dissolving the cyclosporin A in the solvent of choice, which should be purged with an inert gas. Cyclosporin A is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF).

Can you dilute cyclosporine?

This preparation requires dilution to concentrations of 0.5–2.5 mg/mL with 0.9% sodium chloride injection or 5% dextrose injection before administration. However, dilutions as low as 0.2 mg/mL are routinely used in pediatric hospitals.

What do you mix cyclosporine with?

Cyclosporine (modified) oral solution may be mixed with orange juice or apple juice but should not be mixed with milk. Cyclosporine oral solution may be mixed with milk, chocolate milk, or orange juice. You should choose one drink from the appropriate list and always mix your medication with that drink.

How is cyclosporine absorbed?

The absorption of cyclosporine occurs mainly in the intestine. Absorption of cyclosporine is highly variable with a peak bioavailability of 30% sometimes occurring 1-8 hours after administration with a second peak observed in certain patients.

Is cyclosporine acidic or basic?

Cyclosporine A (hereafter cyclosporine) is a neutral, lipophilic, cyclic endecapeptide with a molecular weight of 1202.635 g/mol and low aqueous solubility (Figure 1).

Does cyclosporine come in liquid form?

Cyclosporine dosage The oral medication is available either as a liquid or in capsule form. Liquid cyclosporine is available in 50-ml (5000-mg) bottles (100 mg is equal to 1 ml). After being opened, liquid cyclosporine remains usable for two months.

How do you use cyclosporine oral solution?

Take this medicine the same way every day. Take it at the same time and take it consistently, either with or without food. Measure the oral liquid only with the dosing syringe that comes with the package. The dosing syringe should be wiped with a clean towel after it is used and stored in its container.

Can you crush cyclosporine?

The most important thing to remember is to take it the same way everyday, either with or without food as the food can affect the drugs absorption. The capsules should be swallowed whole and not opened, crushed or chewed.

Is cyclosporine A lipid soluble?

The original formulation of cyclosporine (Sandimmune) is a highly lipid-soluble compound with unpredictable and relatively poor bioavailability.

Where is cyclosporine absorbed?

Cyclosporin was found to be absorbed predominantly in the small intestine. This may have implications for dosage in patients with reduced absorptive surface area.

Is Cyclosporine A prodrug?

Water soluble cyclosporine monomethoxy poly(ethyleneglycol) conjugates as potential prodrugs.