How does salicylic acid cause respiratory alkalosis?
How does salicylic acid cause respiratory alkalosis?
Respiratory centers are directly stimulated, causing a primary respiratory alkalosis. Salicylates also cause an inhibition of the citric acid cycle and an uncoupling of oxidative phosphorylation and may produce renal insufficiency that causes accumulation of phosphoric and sulfuric acids.
How do you monitor salicylate toxicity?
If poisoning is suspected, serum salicylate level (drawn at least a few hours after ingestion), urine pH, ABGs, serum electrolytes, serum creatinine, plasma glucose, and blood urea nitrogen (BUN) are measured.
What is salicylic acid toxicity?
Salicylate levels greater than 100 mg/dL are considered severe toxicity and occur 12 to 24 hours after ingestion. Damage to the basement membranes will cause cerebral and pulmonary edema. Patients may become obtunded and develop seizures.
What causes high salicylate levels?
Dehydration, hyperthermia, and chronic ingestion increase salicylate toxicity because they result in greater distribution of salicylate to tissues. Excretion of salicylates increases when urine pH increases.
How does salicylate inhibit oxidative phosphorylation?
Salicylates cause lactic acidosis by interfering with the enzymes of Krebs cycle. Specifically, alpha-ketoglutarate dehydrogenase and succinic acid dehydrogenase appear to be targets.
What is a normal level for salicylates?
What does the test result mean?
| Salicylate result reported as mg/dL | Salicylate result reported as mcg/mL | Result Interpretation |
|---|---|---|
| 10-30 | 100-300 | Anti-inflammatory level; some symptoms of toxicity may appear, such as headache, tinnitus, vertigo |
| Greater than 30 | Greater than 300 | Considered toxic |
Is salicylate and salicylic acid the same?
A salicylate is a salt or ester of salicylic acid. Salicylates are found naturally in some plants (such as white willow bark and wintergreen leaves) and are thought to protect the plant against insect damage and disease. Aspirin is a derivative of salicylic acid – and is also known as acetylsalicylic acid.
How is salicylate sensitivity diagnosed?
There are no reliable skin or blood tests for the diagnosis of food intolerance. The only way to accurately diagnose a salicylate sensitivity is through a process of dietary elimination and challenge testing. This should always be done under the supervision of a doctor and dietician.
How long does salicylic acid stay in your bloodstream?
6 The half-life of salicylic acid can range from 2 to 12 hours depending on the dose. If 16 g of lotion is applied twice a day, salicylic acid could accumu- late in the body and levels could even become high enough to cause death.
What does salicylate level mean?
What is a salicylates level test? This test measures the amount of salicylates in the blood. Salicylates are a type of drug found in many over-the-counter and prescription medicines. Aspirin is the most common type of salicylate.
