Why is ED pathway used?

Why is ED pathway used?

The Entner-Doudoroff (ED) pathway has recently been shown to play an important role in sugar catabolism for many organisms although very little information is available on the functionality of this pathway in Vibrio cholerae, the causative agent of cholera.

How is ED pathway different from EMP pathway?

In the EMP pathway, glucose is phosphorylated twice, consuming two ATP, and both three-carbon intermediates (glyceraldehyde 3-phosphate, or G3P) enter lower glycolysis to produce two ATP each. In the ED pathway, glucose is only phosphorylated once, consuming one ATP, before being cleaved into one G3P and one pyruvate.

What is the key enzyme of ED pathway?

The key enzyme unique to the ED pathway is 2-keto-3-deoxygluconate-6-phosphate (KDPG) aldolase (Eda), whereas phosphofructokinase (PFK) is unique to the EMP pathway in the catabolic direction (3, 6). KDPG as a metabolite is exclusively found in the ED pathway (Fig. 1).

What is the full form of ED pathway?

The Entner–Doudoroff pathway describes an alternate series of reactions that catabolize glucose to pyruvate using a set of enzymes different from those used in either glycolysis or the pentose phosphate pathway.

Where does ED pathway take place?

The Entner–Doudoroff pathway of glucose catabolism in aerobic and anaerobic Gram-negative bacteria. The ED pathway is found in some Gram-negative bacteria such as Pseudomonas, Rhizobium, and Agrobacterium. It is generally not found in Gram-positive bacteria.

How many ATP are produced in ED pathway?

The prevalence of the ED pathway is puzzling as it produces only one ATP per glucose—half as much as the EMP pathway. We argue that the diversity of prokaryotic glucose metabolism may reflect a tradeoff between a pathway’s energy (ATP) yield and the amount of enzymatic protein required to catalyze pathway flux.

What are the products of the ED pathway?

From each molecule of glucose, the ED pathway produces two molecules of NADPH and one molecule of ATP for use in cellular biosynthetic reactions. Figure 7. The Entner–Doudoroff pathway of glucose catabolism in aerobic and anaerobic Gram-negative bacteria.

Which enzyme is used in ATP generation in EMP?

The upper portion of the EMP pathway invests two ATP molecules to activate (phosphorylate) the hexose sugar glucose, and rearrange it for cleavage into two triose phosphate molecules (Figure 3). The key enzyme is 6- phosphofructokinase (PFK).

Which process is also known as EMP pathway?

Glycolysis is also called EMP pathway.

Does EMP pathway require oxygen?

EMP pathway is also known as glycolysis which is the first step during respiration. It takes place in cytoplasm and does not require oxygen.