When do you use rasburicase?

When do you use rasburicase?

Rasburicase is indicated for use in the pediatric population for the management of elevated uric acid in patients who are receiving chemotherapy for leukemia, lymphoma, or solid tumors and are anticipated to develop tumor lysis and elevated uric acid levels (4).

What type of drug is rasburicase?

Rasburicase injection is in a class of medications called enzymes. It works by breaking down uric acid so that the body can eliminate it.

When do you use rasburicase for TLS?

In contrast to allopurinol, rasburicase reduces preexisting hyperuricemia quickly and does not lead to xanthine accumulation. Therefore, it is suitable for patients with preexisting hyperuricemia before anticancer therapy, patients at high risk for TLS, or patients with spontaneous TLS.

Which drugs cause TLS?

Which agents may cause tumor lysis syndrome (TLS)?

• Paclitaxel.
• Fludarabine.
• Etoposide.
• Thalidomide.
• Bortezomib.
• Zoledronic acid.
• Hydroxyurea.
• Carfilzomib.

Is rasburicase a chemo drug?

Rasburicase is a drug given before and during chemotherapy to treat some types of leukaemia and lymphoma. It can help to prevent tumour lysis syndrome.

How quickly does rasburicase work?

Following administration of either 0.15 or 0.20 mg/kg rasburicase daily for up to 5 days, plasma uric acid levels decreased within 4 hours and were maintained below 7.5 mg/dL in 98% of adult and 90% of pediatric patients for at least 7 days.

What is the mechanism of action of Rasburicase?

What is the mechanism of action? Rasburicase causes an reaction with an enzyme that turns uric acid into an inactive substance, allantoin, thereby reducing uric acid levels.

Is Rasburicase a chemo drug?

When do you give allopurinol after rasburicase?

At the end of the treatment with rasburicase, patients should start receiving oral allopurinol. Rasburicase should be administered at the dose of 0.20 mg/kg/day, infused over 30 minutes, administering the first dose at least four hours before the start of tumor-specific therapy and continuing for at least 3–5 days.

Why is rasburicase not used for gout?

Tolerance of rasburicase in gout appears to be marred by the very frequent triggering of gout attacks. Moreover, hypersensitivity reactions can occur, as in 2 of our patients, and are likely to be an important limitation to longterm therapy with this drug.

When was rasburicase approved by the FDA?

Cite this: FDA Approves Rasburicase for Use in Adult Cancer Patients – Medscape – Oct 21, 2009.

How do you give rasburicase?

Rasburicase is given once a day for 5 days. Timing of cancer chemotherapy and rasburicase doses is important. Chemotherapy is usually started 4 to 24 hours after the first dose of rasburicase. Fluids are also given into the vein with this medication to help decrease your uric acid levels.