What is pegylated liposomal doxorubicin?

Pegylated liposomal doxorubicin is a formulation of doxorubicin in which the molecule itself is packaged in a liposome made of various lipids with an outer coating of polyethylene glycol. Liposomal technology is being used in increasing amounts in the therapy of a variety of cancers, including ovarian cancers.

What is liposomal doxorubicin used for?

Doxorubicin liposome injection is used to treat ovarian cancer and Kaposi sarcoma (AIDS patients). It is also used together with bortezomib to treat multiple myeloma. Doxorubicin liposome is an antineoplastic agent (cancer medicine).

Is liposomal doxorubicin a chemotherapy?

Liposomal doxorubicin is a chemotherapy drug that is also called by the brand names Caelyx or Myocet. It contains the chemotherapy drug doxorubicin (Adriamycin) wrapped up in a fatty covering called a liposome. It is a treatment for some types of cancer, including: breast cancer.

How does Caelyx deliver doxorubicin?

Caelyx consists of a liposomal formulation of doxorubicin HCl encapsulated in a delivery system of long circulating liposomes (Stealth® or sterically stabilised liposomes) with surface-bound methoxy- polyethylene glycol distearoylphosphoethanolamine sodium salt (MPEG-DSPE).

Does liposomal doxorubicin cause hair loss?

v Hair loss is unusual with liposomal doxorubicin, but some patients do experience more hair loss than others. If hair loss occurs, hair growth should return upon completion of treatment. v Nausea and vomiting are not unusual but are less common today than in the past because of much improved anti-nausea medications.

How do you give liposomal doxorubicin?

This medication is given by injection through a vein (intravenously, by IV). Doxorubicin (liposomal) is an irritant. An irritant is a chemical that can cause inflammation of the vein through which it is given. If the medication escapes from the vein it can cause tissue damage.

Is doxorubicin the Red Devil?

This agent has earned its infamous nickname, the red devil, based on its bright red (Kool-Aid red) color, vesicant properties, and side-effect profile, including hair loss, myelosuppression, nausea and vomiting, mouth sores, and rare but serious cardiotoxicity.

How effective is Caelyx?

For metastatic breast cancer, in a study involving 509 women, Caelyx pegylated liposomal was as effective as standard doxorubicin: the time until the disease got worse was around 7.5 months in both groups. However, patients receiving Caelyx pegylated liposomal were less likely to have heart problems.

Is caelyx the same as Doxil?

Liposomal doxorubicin is known as Doxil® in the US and Caelyx® in Canada. Doxil is currently approved for the treatment of AIDS-related Kaposi sarcoma and ovarian cancer.

How long after doxorubicin does hair fall out?

Your hair may become thin, brittle, or may fall out. This typically begins two to three weeks after treatment starts. This hair loss can be all body hair, including pubic, underarm, legs/arms, eyelashes, and nose hairs. The use of scarves, wigs, hats, and hairpieces may help.

How many cycles of doxorubicin are there?

Six Cycles of Doxorubicin and Cyclophosphamide or Paclitaxel Are Not Superior to Four Cycles As Adjuvant Chemotherapy for Breast Cancer in Women With Zero to Three Positive Axillary Nodes: Cancer and Leukemia Group B 40101. Lawrence N.