How often should teicoplanin be given?

How often should teicoplanin be given?

A pre-dose (trough) level should be taken on day 4, then weekly thereafter. Teicoplanin levels can be prescribed on EPMA….Quick Launch.

How do you administer IV teicoplanin?

Directions for administration For intravenous infusion (Targocid ®), manufacturer advises give intermittently in Glucose 5% or Sodium chloride 0.9%; reconstitute initially with water for injections provided; infuse over 30 minutes. Continuous infusion not usually recommended.

When is teicoplanin used?

Teicoplanin is an antibiotic that is used to prevent and treat Gram-positive bacterial infections, such as methicillin-resistant Staphylococcus aureus and Enterococcus faecalis. It’s a semisynthetic glycopeptide antibiotic that works in a similar way to vancomycin.

Why is teicoplanin given?

Teicoplanin is a useful glycopeptide antibiotic which is used to treat serious staphylococcal and streptococcal infections but has no gram negative activity. It has the advantage of requiring less frequent monitoring compared to vancomycin and is also less nephrotoxic.

How long is a course of teicoplanin?

The duration of treatment should be decided based on the clinical response. For infective endocarditis a minimum of 21 days is usually considered appropriate. Treatment should not exceed 4 months. Teicoplanin has a limited spectrum of antibacterial activity (Gram positive).

How do you monitor teicoplanin?

Teicoplanin trough serum concentrations should be monitored after completion of the loading dose regimen and during maintenance treatment in order to ensure that a minimum trough serum concentration has been reached. Pharmacist). Take a trough level (just before the next scheduled dose) on Day 5.

Is teicoplanin nephrotoxic?

Teicoplanin is nephrotoxic in animals, although at much higher doses than those used in humans. This antibiotic also appears to have less nephrotoxic synergism with aminoglycosides than vancomycin.

What is the difference between vancomycin and teicoplanin?

Vancomycin can, however, provoke a number of side-effects, and serum concentrations should be monitored during treatment. Teicoplanin has a longer half-life than vancomycin, it can be given as an intravenous bolus or by intramuscular injection, and nephrotoxicity and ototoxicity are relatively uncommon.

What class of antibiotic is teicoplanin?

Drug action The glycopeptide antibiotic teicoplanin has bactericidal activity against aerobic and anaerobic Gram-positive bacteria including multi-resistant staphylococci.

Is teicoplanin a broad spectrum antibiotic?

Teicoplanin Reprogrammed with the N-Acyl-Glucosamine Pharmacophore at the Penultimate Residue of Aglycone Acquires Broad-Spectrum Antimicrobial Activities Effectively Killing Gram-Positive and -Negative Pathogens.

When should teicoplanin levels be checked?

When to test

1. The initial pre-dose assay sample should be collected just before the dose given on the 5th day.
2. If a patient is on a prolonged course of teicoplanin (>2 weeks) and the initial levels are satisfactory, repeat levels should be monitored weekly.

What are the side effects of teicoplanin?

Common adverse effects include rashes, fever, pruritus, diarrhoea, nausea and vomiting. Ototoxicity has been reported so auditory function should be monitored if other neurotoxic drugs, e.g. aminoglycosides, are being given or treatment is prolonged in a patient with renal insufficiency.