How does sickle cell anemia cause priapism?
How does sickle cell anemia cause priapism?
In a child with sickle cell disease, the sickling of red blood cells can cause an erection. Blood is unable to flow out of the penis because the vessels are blocked by sickled blood cells. If the erection continues, this is called priapism.
What causes priapism?
Alcohol, marijuana, cocaine and other drugs can cause priapism, particularly ischemic priapism.
What is Priya prism?
Priapism is a persistent, usually painful, erection that lasts for more than four hours and occurs without sexual stimulation. The condition develops when blood in the penis becomes trapped and is unable to drain.
How common is priapism in sickle cell disease?
Sickle cell anemia is a common and disabling disorder profoundly affecting mortality as well as quality of life. Up to 35% of men with sickle cell disease are affected by painful, prolonged erections termed ischemic priapism. A priapic episode may result in fibrosis and permanent erectile dysfunction.
How is sickle cell priapism treated?
Key steps in the management of sickle cell disease–associated priapism include oxygenation, analgesics (eg, intravenous morphine), hydration, alkalization, and exchange transfusions to increase the hematocrit value to greater than 30% and to decrease the hemoglobin S (HbS) value to less than 30%.
What causes child priapism?
The commonest causes of priapism in children are sickle cell disease (65%), leukaemia (10%), trauma (10%), idiopathic (10%), and pharmacologically induced (5%). Conclusions: Priapism in children must be assessed urgently.
What damage can priapism cause?
An erection that lasts longer than four hours is a medical emergency. The oxygen-deprived blood in your penis can damage tissue in the penis. Untreated priapism can result in damage or destruction of penile tissue and permanent erectile dysfunction.
What drugs can cause priapism?
Table 1: Medicines associated with priapism
| Medicine class | Examples |
|---|---|
| Antipsychotics & Antidepressants | risperidone, olanzapine, clozapine, chlorpromazine, quetiapine, sertraline, citalopram, escitalopram, lithium, fluoxetine, trifluoperazine, pericyazine |
| Vasoactive erectile agents | alprostadil, papaverine |
Is priapism genetic?
Abstract. Priapism occurs in 30-45% of male patients with sickle cell disease (SCD), but the possible influence of genetic risk factors on the incidence of priapism is not well understood.
How do you reverse priapism?
Treatment
- Aspiration decompression. Excess blood is drained from your penis using a small needle and syringe (aspiration).
- Medications. A medication, such as phenylephrine, might be injected into your penis.
- Surgery or other procedures.
What is the meaning of priapism?
Priapism is a prolonged and often painful erection of the penis. It causes blood in the penis to become trapped and unable to drain through the penile arteries. It is often unrelated to or continues long beyond sexual activity. It can be a serious condition due to the risk of permanent tissue damage.
