What is normal alkaline phosphatase during pregnancy?

Background. The normal serum concentration of alkaline phosphatase (ALP) in adults over the age of 18 ranges from 37 to 116 U/L, while in pregnant women levels of up to twice that upper limit can still be normal.

Can pregnancy cause high ALT levels?

Laboratory Studies Aspartate transaminase (AST) and alanine transaminase (ALT) are not elevated in normal pregnancies. These can become elevated in many different conditions during pregnancy. Some are unique to pregnancy, such as preeclampsia/eclampsia, HELLP, and AFLP.

What if alkaline phosphatase is high in pregnancy?

Increased levels of alkaline phosphatase (ALP) should alert us to changes in the liver, kidney, bone and malignancy. However, there is a physiological increase in pregnancy up to twice the upper limit. There has been a paucity of cases reporting extreme elevations of ALP in pregnancy.

Can high alkaline phosphatase mean preeclampsia?

The elevated levels of serum PLAP and ALP in hypertensive pregnant women may be attributed to placental dysfunction, which results in increased serum levels of these enzymes. Shedding of syncytiotrophoblast into the maternal circulation is a normal part of pregnancy, but is increased during pre-eclampsia.

Why is alkaline phosphatase high in pregnancy?

Serum alkaline phosphatase activity increases in late pregnancy, due both to the production of the placental isoenzyme and to the increase in bone isoenzyme. Consequently, measurement of serum alkaline phosphatase levels is not a suitable test for the diagnosis of cholestasis during pregnancy.

Why is alkaline phosphatase high in preeclampsia?

What can cause liver enzymes to be high during pregnancy?

During the last trimester, the metabolic demands of the fetus increase, and mothers heterozygous for a fatty acid oxidation disorder and pregnant with an affected fetus can develop AFLP because of their inability to metabolize fatty acids for energy production and fetal growth. Fatty acids then deposit in the liver.

Does high alkaline phosphatase mean cholestasis?

Alkaline Phosphatase: Alkaline phosphatase is produced by the placenta and is normally elevated in pregnancy. Therefore, elevation of ALP/ALK (alkaline phosphatase) alone does not provide an indication of Intrahepatic Cholestasis of Pregnancy.

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