Which is the derivative of adamantane?
Which is the derivative of adamantane?
The adamantane derivatives, amantadine hydrochloride and rimantadine hydrochloride, inhibit viral replication by blocking the proton channel formed by the M2 protein of influenza A viruses.
What conformation of cyclohexane is adamantane?
Adamantane molecules can be described as the fusion of three cyclohexane rings. The molecule is both rigid and virtually stress-free. Adamantane is the most stable isomer of C10H16….Adamantane.
| Names | |
|---|---|
| Preferred IUPAC name Adamantane | |
| Systematic IUPAC name Tricyclo[3.3.1.13,7]decane | |
| Identifiers | |
| CAS Number | 281-23-2 |
What is adamantane used for?
Answer. Amantadine and rimantadine are antiviral drugs in a class of medications known as adamantanes that were once prescribed for influenza treatment or prophylaxis. These medications are active against influenza A viruses, but not influenza B viruses.
Is adamantane aromatic?
Degeneracy in energy of the bridged atoms, uniformity and magnitude of their shared charge distinguish the dications 1,3-adamantyl and the 1,3-dehydro-5,7-adamantanediyl. However, both are aromatic as well as the 1,3-dehydro-5,7-diboroadamantane.
What is the mechanism of action of amantadine?
Amantadine is an antiviral agent that has antiparkinsonian activity. Its mechanism of action is not fully understood, but amantadine appears to potentiate CNS dopaminergic responses. It may release dopamine and norepinephrine from storage sites and inhibit the reuptake of dopamine and norepinephrine.
What is the point group of adamantane?
Adamantane is a small hydrocarbon molecule with pure sp3 hybridized carbon atoms arranged in a tetrahedral point group, often referred to as a diamondoid.
What is axial and equatorial position?
Axial positions are perpendicular to the plane of the ring and equatorial positions are around the plane of the ring. The bond angles in this conformation are 110.9˚
Can viruses become resistant to antivirals?
Reduced susceptibility detected using laboratory tests can be a sign of potential antiviral drug resistance in clinical settings. Typically, flu virus is called resistant after sufficient evidence was gathered to prove a lack of antiviral effect of a particular antiviral medication in patients infected with such virus.
What class of medication is amantadine?
Amantadine is in a class of medications called adamantanes. It is thought to work to control movement problems by increasing the amount of dopamine in certain parts of the body.
What are the side effects of the drug amantadine?
Blurred vision, nausea, loss of appetite, drowsiness, dizziness, lightheadedness, headache, dry mouth, constipation, or trouble sleeping may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.
