What diseases are type 2 hypersensitivity?
What diseases are type 2 hypersensitivity?
Examples
| Disease | Autoantibody target |
|---|---|
| Autoimmune hemolytic anemia | Red blood cells |
| Goodpasture syndrome | Glomerular basement membrane |
| Graves disease | Thyroid stimulating hormone receptor |
| Immune thrombocytopenia | Platelets |
What are examples of type II hypersensitivity reactions?
Examples of type II HS include some forms of anemia, blood transfusion reactions, certain platelet disorders, and some types of tissue transplant rejection.
What causes type II hypersensitivity?
Type II hypersensitivity reactions (Fig. 46-2) are caused by chemical modification of cell surface or matrix-associated antigens that generates “foreign” epitopes to which the immune system is not tolerant.
What are the diseases caused by hypersensitivity reactions?
Type I hypersensitivity or allergy, the most common immune disorder, is mainly mediated by immunoglobulin (Ig)E and mast cells. It can cause anaphylaxis, food allergy, and asthma.
Is rheumatoid arthritis a Type 2 hypersensitivity?
Diseases associated with type III hypersensitivity reactions are most commonly associated with a single exposure to a large quantity of antigen (e.g., administration of heterologous serum or from an immune response to systemic infections) or from continuous exposures to small quantities of antigen as in the case of …
Is rheumatic fever type 2 hypersensitivity?
Autoimmune reactions in ARF and RHD are caused by molecular mimicry between Streptococcus pyogenes antigens and human proteins which is a type II hypersensitivity [3].
What type of hypersensitivity is Guillain Barre?
The Guillain-Barré syndrome is hypothesized to be secondary to cellular hypersensitivity to peripheral nerve antigens.
What type of hypersensitivity is lupus?
SLE is a prototype type III hypersensitivity reaction. Local deposition of anti-nuclear antibodies in complex with released chromatin induces serious inflammatory conditions by activation of the complement system.
Is SLE type 2 hypersensitivity?
Statistics on Hypersensitivity reaction – Type II Note that systemic lupus erythematosus is a disease of mixed hypersensitivity – type II and III hypersensitivity reaction occur in this disease.
What type of hypersensitivity is diabetes?
Type III Hypersensitivity Reaction to Subcutaneous Insulin Preparations in a Type 1 Diabetic.
What type of hypersensitivity is myasthenia gravis?
Myasthenia gravis is an autoimmune disease that’s categorized as a type II hypersensitivity that involves autoantibodies binding acetylcholine receptors on skeletal muscle cells.
