Where does mevalonic acid pathway occur?
Where does mevalonic acid pathway occur?
cytosol
In higher plants, the MEP pathway operates in plastids while the mevalonate pathway operates in the cytosol. Examples of bacteria that contain the MEP pathway include Escherichia coli and pathogens such as Mycobacterium tuberculosis.
Which can be produced through mevalonic acid pathway?
The function of the mevalonate pathway is the production of cholesterol as well as the synthesis of isoprenoid lipids such as farnesyl diphosphate (FPP) and geranylgeranyl diphosphate (GGPP).
What is the function of mevalonic acid?
Mevalonic acid is a precursor in the biosynthetic pathway known as the mevalonate pathway that produces terpenes and steroids. Mevalonic acid is the primary precursor of isopentenyl pyrophosphate (IPP), that is in turn the basis for all terpenoids.
What is the meaning of mevalonate pathway?
Listen to pronunciation. (meh-VA-loh-nayt PATH-way) Describes a series of reactions in which proteins work together to make molecules. These molecules are part of many processes, including making cholesterol.
Why is mevalonate pathway important?
The mevalonate pathway, fundamental for cholesterol synthesis, is one of the most important metabolic networks in the cell; it provides essential cell constituents, such as cholesterol, and some of its branches produce key metabolites, such as geranylgeranyl pyrophosphate and farnesyl pyrophosphate, necessary for …
How is mevalonic acid produced?
Mevalonate is produced by the NADPH-dependent reduction of HMG coA by HMG coA reductase. This last step in mevalonate construction is considered to be the rate-limiting step for the MVA pathway.
What is HMG pathway?
HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-coenzyme A reductase, official symbol HMGCR) is the rate-controlling enzyme (NADH-dependent, EC 1.1. 1.88; NADPH-dependent, EC 1.1. 1.34) of the mevalonate pathway, the metabolic pathway that produces cholesterol and other isoprenoids.
What does the shikimate pathway produce?
In microorganisms, the shikimate pathway produces aromatic amino acids L-phenylalanine (L-Phe), L-tyrosine (L-Tyr), and L-tryptophan (L-Trp), molecular building blocks for protein biosynthesis [9].
How is mevalonate pathway regulated?
The MVA biosynthetic pathway is regulated by transcriptional and post-transcriptional mechanisms including modulation of gene transcription, mRNA translation, protein degradation, and enzymatic activity (44, 49).
Which drug inhibits mevalonic acid pathway?
Statins are antidyslipidemic drugs that inhibit hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase in the upstream part of the mevalonate pathway and reduce cholesterol levels in blood [5].
