Why is mitomycin used in pterygium surgery?

Mitomycin C (MMC) has been used as a fibroblast proliferation inhibitor during the surgery to reduce the chance of recurrence of the pterygium.

What are the complications of pterygium?

The complications post pterygium excision and auto-grafting include subconjunctival hemorrhage, graft edema, graft loss, retraction, graft sliding, granuloma, and recurrence.

How do you dilute mitomycin C for pterygium?

Mitomycin C in the form of eye drops in a concentration of 0.4 mg/ml (0.04%) was used as adjunctive treatment for primary and recurrent pterygium after surgical excision. The study was concurrent in nature and consisted of 32 pterygia in 30 patients and was done over a period of 36 months.

What is mitomycin C in eye surgery?

Mitomycin C is an antimetabolite applied between the sclera and conjunctiva during the initial stages of a trabeculectomy to prevent excessive post-operative scarring and thus reduce the risk of failure.

Is pterygium surgery risky?

Although complications are very low or rare with qualified surgeons utilising the PERFECT Pterygium technique they are still possible. They might include but not limited to: The formation of a cyst, infection, or proud flesh requiring further treatment or surgery – 1 in 400.

Why does diplopia occur in pterygium?

In patients with pterygia who have previously undergone surgical excision, scarring or disinsertion of the medial rectus muscle is the most common cause of diplopia. In patients with significantly elevated pterygia, focal drying and subsequent thinning of the adjacent cornea may rarely occur.

How do you prevent pterygium recurrence?

Preoperative subpterygium-combined injection of bevacizumab and mitomycin C is safe and effective in reducing the postoperative recurrence of primary pterygium, especially if applied 1 month before surgery.

How is mitomycin C 0.02 Prepared?

Our preparation of the mitomycin-C includes mixing the drug with a sterile water diluent to achieve a starting concentration of 0.2 mg/ml. This is then diluted further with 2% lidocaine—the same lidocaine we would use in a retrobulbar block.

What are the side effects of Mitomycin?

Mitomycin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • nausea.
  • vomiting.
  • loss of appetite or weight.
  • sores in the mouth and throat.
  • headache.
  • fainting.
  • blurred vision.
  • hair loss.