WHO guidelines MDR TB treatment?

Current policy recommendations on treatment and care for DR-TB. In patients with confirmed rifampicin-susceptible and isoniazid-resistant tuberculosis, treatment with rifampicin, ethambutol, pyrazinamide and levofloxacin is recommended for a duration of 6 months.

Which is included in Rntcp?

The RNTCP will be using a standardized treatment regimen (STR), comprising of 6 drugs (kanamycin, ofloxacin, ethionamide, pyrazinamide, ethambutol, and cycloserine) during 6–9 months of the Intensive Phase and 4 drugs (ofloxacin, ethionamide, ethambutol, and cycloserine) during the 18 months of the Continuation Phase.

What is the MDR in MDR TB?

Multidrug-resistant tuberculosis (MDR-TB) is a form of tuberculosis (TB) infection caused by bacteria that are resistant to treatment with at least two of the most powerful first-line anti-TB medications (drugs), isoniazid and rifampin.

Which drugs are used for treatment of MDR TB?

MDR regimens should include at least pyrazinamide, a fluoroquinolone, an injectable anti-TB drug, ethionamide (or prothionamide) and either cycloserine or PAS (para-aminosalycylic acid) if cycloserine cannot be used (conditional recommendation, very low quality evidence)(1).

What is the duration of treatment of MDR-TB?

According to the new 2019 updated WHO DR-TB guidelines, a longer MDR-TB regimen can be used for MDR/RR-TB, lasts for at least 18 months, and can be either standardized or individualized. A shorter MDR-TB regimen can be used for MDR/RR-TB, is largely standardized, and is given for 9 to 12 months (Fig.

How do you confirm MDR-TB?

Drug resistance can be detected using special laboratory tests which test the bacteria for sensitivity to the drugs or detect resistance patterns. These tests can be molecular in type (such as Xpert MTB/RIF) or else culture-based.

What is new name of RNTCP?

the National Tuberculosis Elimination Programme (NTEP)
It is no longer known as the Revised National TB Control Programme (RNTCP), and has been rechristened as the National Tuberculosis Elimination Programme (NTEP). The change in name is in line with the larger goal of eliminating the disease by 2025, five years ahead of the Sustainable Development Goals target.

What is DOTS in RNTCP?

Introduction: Directly observed treatment short-course (DOTS) strategy is one of the vital components of Revised National Tuberculosis Control Programme (RNTCP) came into existence in 1997. Directly observed treatment providers (DOT providers) are the grass root level link between program and clients.

How MDR-TB is diagnosed?

Successful diagnosis and treatment of MDR-TB are based on a rapid and precise drug sensitivity test (DST), which provides evidence for selecting an effective drug [4].

What is the difference between MDR and XDR-TB?

Multidrug-resistant tuberculosis (MDR-TB) is practically incurable by standard first-line treatment. However, extensively drug-resistant tuberculosis (XDR-TB) is resistant to both first- and second-line drugs due to drug misuse and mismanagement. Therefore, XDR-TB treatment becomes even harder.

How long is MDR-TB treatment?

How is MDR-TB diagnosed?