Which medication is a glycoprotein IIb IIIa inhibitor?

The available GP IIb/IIIa inhibitors include abciximab, tirofiban, and eptifibatide. These agents, along with aspirin, are used in patients with unstable angina with PCI within 24 hrs.

Which of the following drug is an inhibitor of platelets glycoprotein GP IIb IIIa receptors?

Eptifibatide (Integrilin) is an antagonist of the platelet GP IIb/IIIa receptor; it reversibly prevents von Willebrand factor, fibrinogen, and other adhesion ligands from binding to the GP IIb/IIIa receptor. The end effect is the inhibition of platelet aggregation.

What is IIb IIIa antibody?

In medicine, glycoprotein IIb/IIIa (GPIIb/IIIa, also known as integrin αIIbβ3) is an integrin complex found on platelets. It is a receptor for fibrinogen and von Willebrand factor and aids platelet activation.

Is abciximab reversed?

Abciximab should be discontinued 12–24 h before procedure. Currently, there is no available reversal agent. Therefore, platelet transfusion is recommended for reversing the effect of abciximab. Eptifibatide (Integrilin) is approved for use in patients with acute coronary syndrome, including patients scheduled for PCI.

What is the function of glycoprotein IIb IIIa?

Glycoprotein IIb/IIIa (GPIIb/IIIa) plays a major role in the regulation of platelet adhesion and aggregation during haemostasis. Upon platelet activation by an agonist a signalling process is initiated, termed “inside-out” signalling, which gives rise to conformational changes within GPIIb/IIIa.

Why was abciximab discontinued?

Why was abciximab discontinued? The manufacturer, Janssen, reported an interruption in production at one of their manufacturing sites. They made the decision to remove abciximab from the market in the United States voluntarily, and their decision wasn’t due to any safety issues.

What is abciximab infusion used for?

Abciximab is used to lessen the chance of heart attack in people who need percutaneous coronary intervention (PCI), a procedure to open blocked arteries of the heart.