Where is the blood retinal barrier?

Blood–retinal barrier The outer BRB is located at the tight junctions between the apical lateral membranes of the RPE cells. Its integrity is fundamentally important for the health and integrity of the inner retina.

What are the two components of the blood retinal barrier?

the blood retinal barrier (BRB), which is located in the posterior part of the eye and is composed of two types of cells, i.e., the retinal capillary endothelial cells and the retinal pigment epithelial (RPE) cells, which constitute the inner and the outer BRB, respectively (Cunha-Vaz et al., 2011; Campbell and …

What structure establishes the blood retina barrier?

While the inner blood retina barrier (iBRB) is composed of tight junctions (TJs) between retinal capillary endothelial cells, the so-called outer blood retina barrier (oBRB) is formed by the TJs between retinal pigment epithelial (RPE) cells.

What is blood aqueous barrier?

The blood-aqueous barrier is formed by an epithelial barrier located in the nonpigmented layer of the ciliary epithelium and in the posterior iridial epithelium, and by the endothelium of the iridial vessels. Both these layers have tight junctions of the “leaky” type.

What is the outermost layer of the retina?

The pigment epithelium is the most external layer of the retina. It abuts on the choroidal layer of the eye. It contains a single layer of cuboidal-supporting cells for the neural portion of the retina. These cells contain melanin, which absorbs light and decreases light scatter within the eye.

What is Pericyte?

Pericytes are cells present at intervals along the walls of capillaries (and post-capillary venules). In the CNS, they are important for blood vessel formation, maintenance of the blood–brain barrier, regulation of immune cell entry to the central nervous system (CNS) and control of brain blood flow.

What is blood vitreous barrier?

The blood–ocular barrier is a barrier created by endothelium of capillaries of the retina and iris, ciliary epithelium and retinal pigment epithelium. It is a physical barrier between the local blood vessels and most parts of the eye itself, and stops many substances including drugs from traveling across it.

What are the 10 retinal layers?

(1) retinal pigment epithelium; (2) rods and cones (photoreceptors); (3) external limiting membrane; (4) outer nuclear layer; (5) outer plexiform layer; (6) inner nuclear layer; (7) inner plexiform layer; (8) ganglion cell layer; (9) nerve fiber layer; (10) inner limiting membrane; (11) vitreous.

What is the blood–retinal barrier?

The blood–retinal barrier, or the BRB, is part of the blood–ocular barrier that consists of cells that are joined tightly together to prevent certain substances from entering the tissue of the retina.

Why is the retinal barrier important for homeostasis?

The tight junctions located between these cells mediate highly selective diffusion of molecules from the blood to the retina and the barrier is essential in maintaining retinal homeostasis.

How does diabetes affect the blood–retinal barrier?

These junctions are impervious to tracer, so many substances can affect the metabolism of the eyeball. The retinal pigment epithelium maintains the outer blood–retinal barrier. Diabetic retinopathy, eye damage that frequently occurs as a result of diabetes, is related to the breakdown of the blood–retinal barrier.

What is the function of the blood-retina barrier?

The blood-retina barrier (BRB) is composed of both an inner and an outer barrier. The outer BRB refers to the barrier formed at the retinal pigment epithelial (RPE) cell layer and functions, in part, to regulate the movement of solutes and nutrients from the choroid to the sub-retinal space.