Where is cathepsin C found?

The cathepsin C gene is located on chromosome 11q14. 1–q14. 21, and encodes a lysosomal cysteine protease, also known as dipeptidyl-peptidase 1 (DPPI). It functions by removing dipeptides from the amino terminal of the protein substrate.

What does cathepsin K do?

Cathepsin K (CatK) is one of the most potent proteases in lysosomal cysteine proteases family, of which main function is to mediate bone resorption. Currently, CatK is among the most attractive targets for anti-osteoporosis drug development.

What is cathepsin S activity?

Cathepsin S (CTSS) is a protease located in lysosomes or endosomes of professional antigen presenting cells (APC), such as macrophages, dendritic cells and B cells1. Dysregulated CTSS expression and/or activity has been reported to be involved in the pathogenesis of various diseases.

What is cathepsin protein?

Cathepsins are proteases, which are enzymes that are responsible for degrading proteins. There are around 12 different types of cathepsins. Each cathepsin works to degrade a different protein, and they have different structures and work via different mechanisms.

Where is cathepsin K expressed?

Cathepsin K inhibitors Cathepsin K is a lysosomal cysteine protease, predominantly expressed on osteoclasts, that plays a role in bone resorption by degrading type 1 collagen, which corresponds to around 90% of bone matrix protein [77–79].

How does cathepsin a work?

Cathepsins are the most abundant lysosomal proteases that are mainly found in acidic endo/lysosomal compartments where they play a vital role in intracellular protein degradation, energy metabolism, and immune responses among a host of other functions.

Where is cathepsin A found?

Cathepsins (Ancient Greek kata- “down” and hepsein “boil”; abbreviated CTS) are proteases (enzymes that degrade proteins) found in all animals as well as other organisms.

What is the monoclonal antibody used for the treatment of osteoporosis?

Denosumab. Denosumab, also known as AMG 162, is a fully human monoclonal antibody that binds to RANKL with high affinity, mimicking the effects of OPG on RANKL. Therefore, denosumab can block the differentiation of osteoclasts, resulting in inhibition of osteoclast-mediated bone resorption.