Where is basic fibroblast growth factor?
Where is basic fibroblast growth factor?
Basic fibroblast growth factor
| Gene location (Human) | ||
|---|---|---|
| Chr. | Chromosome 4 (human) | |
| Band | 4q28.1 | Start |
| End |
What is FGF signaling?
FGF/FGFR signaling governs fundamental cellular processes such as cell survival, proliferation, migration, differentiation, embryonic development, organogenesis, tissue repair/regeneration, and metabolism.
How many FGF genes are there?
Human FGFs contain 22 members: FGF1, FGF2, FGF3 (INT2), FGF4, FGF5, FGF6, FGF7 (KGF), FGF8 (AIGF), FGF9, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF20, FGF21, FGF22, and FGF23 [11]. The FGF family comprises 23 members, although there are only 18 FGFR ligands.
What is FGF protein?
Fibroblast growth factor (FGF) is a representative growth factor which has shown the potential effects on the repair and regeneration of tissues [2–6]. It was originally identified as a protein capable of promoting fibroblast proliferation and is now known to comprise 22 members.
What does FGF induce in development?
FGF signaling has also been implicated in limb bud development. In particular, FGF signaling mediates a positive feedback loop of paracrine signaling between mesenchymal and epithelial tissues that pattern the emerging limb bud and stimulate the outgrowth, morphogenesis, and maintenance of early limb structure.
How many FGF receptors are there?
four members
The human fibroblast growth factor receptor (FGFR) family consists of four members: FGFR1 to FGFR4.
What is FGF signal?
Fibroblast Growth Factor (FGF) Signaling Background FGFs that signal through FGF receptors (FGFRs) regulate fundamental developmental pathways, controlling events such as mesoderm patterning in the early embryo through to the development of multiple organ systems.
