What type of cells line the collecting duct of the kidney?
What type of cells line the collecting duct of the kidney?
cuboidal epithelium
Most of the collecting duct system is lined by a cuboidal epithelium containing two types of cells—principal cells and intercalated cells (see Fig.
Where are type B intercalated cells?
At least two populations of intercalated cells, type A and type B, exist in the connecting tubule (CNT), initial collecting tubule (ICT), and cortical collecting duct (CCD).
What is intercalated cells in the collecting duct?
Intercalated cells are epithelial cells traditionally associated with the regulation of acid-base homeostasis in distal segments of the kidney tubule (Figure 1) (1). These cells also participate in potassium and ammonia transport and have a role in the innate immune system.
What is the collecting duct derived from?
The collecting duct system of the metanephric kidney develops from the ureteric bud, an outgrowth from the caudal end of the Wolffian duct. The ureteric bud is induced to form by signals emanating from a specific area of intermediate mesoderm, which it immediately invades.
What are principal cells and intercalated cells?
Principal cells are the main Na+ reabsorbing cells and the site of action of aldosterone, K+-sparing diuretics, and spironolactone. Type A and B intercalated cells make up the second cell type in the collecting duct epithelium. Type A intercalated cells mediate acid secretion and bicarbonate reabsorption.
What are alpha-intercalated cells?
The alpha-intercalated cells (on the left in the figure) are tall, columnar epithelial cells which contain apical H+ ATPase, explaining its ability to secrete protons.
What do principal and intercalated cells do?
What is reabsorbed in the collecting duct?
Water Reabsorption in the Collecting Duct The main role of the collecting duct is the reabsorption of water, through the action of anti-diuretic hormone (ADH) and aquaporins. ADH is produced in the hypothalamus, and stored in the posterior pituitary gland until it is released.
What substances are reabsorbed in collecting duct?
Learning Objectives
| Table 1. Substances Secreted or Reabsorbed in the Nephron and Their Locations | ||
|---|---|---|
| Substance | PCT | Collecting ducts |
| Potassium | 65 percent reabsorbed; diffusion | Secretion controlled by aldosterone; active |
| Calcium | Reabsorbed; diffusion | Reabsorbed if parathyroid hormone present; active |
| Magnesium | Reabsorbed; diffusion |
Which structure leads to the collecting duct?
The proximal convoluted tubule leads to the loop of Henle. This then leads to the distal convoluted tubule. The distal convoluted tubule then leads to the collecting duct.
What is absorbed in the collecting duct?
What is the difference between collecting tubule and collecting duct?
The initial collecting tubule is a segment with a constitution similar as the collecting duct, but before the convergence with other tubules. The “cortical collecting ducts” receive filtrate from multiple initial collecting tubules and descend into the renal medulla to form medullary collecting ducts.
