What type of cancer is MDA-MB-231?

The MDA-MB-231 cell line is an epithelial, human breast cancer cell line that was established from a pleural effusion of a 51-year-old caucasian female with a metastatic mammary adenocarcinoma1 and is one of the most commonly used breast cancer cell lines in medical research laboratories.

How long does it take to administer doxorubicin?

To avoid acute adverse effects, doxorubicin is administered as a carefully controlled slow infusion, generally over 15 to 20 minutes.

What is the ic50 of doxorubicin?

The IC50 values of doxorubicin decreased from 1.14 to 0.54 μM in the BT474 cells, from 0.69 to 0.37 μM in the MCF-7 cells, from 3.16 to 1.25 μM in the MDA-MB-231 cells, from 0.89 to 0.46 μM in the MDA-MB-361 cells, from 1.22 to 0.51 μM in the MDA-MB-435 cells, from 0.69 to 0.27 μM in the MDA-MB-453 cells, from 0.27 to …

How effective is doxorubicin for breast cancer?

Resistance to chemotherapeutic drugs can cause treatment failure in over 90% of patients with metastatic cancer [2]. Doxorubicin (DXR) is part of the anthracycline family and is currently the most effective chemotherapeutic drug used to treat breast cancer [3, 4].

How many times can you get doxorubicin?

This medicine is given through a needle placed in one of your veins. The medicine is usually given once every 21 to 28 days. You may also receive other medicines to help prevent nausea and vomiting.

How many doses of doxorubicin can you have?

Administration of doxorubicin in a weekly regimen has been shown to be as effective as the three weekly regimen. The recommended dosage is 20 mg/m2 once a week although objective responses have been seen at 6-12 mg/m2. This regimen of weekly dosing also reduces the incidence of cardiotoxicity.

What is IC value?

In pharmacology, it is an important measure of potency for a given agent. As reported by the FDA, the IC50 value represents the minimal concentration of a drug that is required for 50% inhibition in vitro. Traditionally, this value is expressed as a molar concentration.

What is the strongest chemo for breast cancer?

Doxorubicin is considered one of the strongest chemotherapy drugs for breast cancer ever invented. It can kill cancer cells at every point in their life cycle, and it’s used to treat a wide variety of cancers, not just breast cancer. Doxorubicin is also known as “The Red Devil” because it is a clear bright red color.

What are the long term effects of doxorubicin?

One notable example is heart damage following treatment with Adriamycin (doxorubicin). With this drug, a possible long-term side effect is weakening of the heart muscle, resulting in heart failure (a decreased ability to pump blood through the body).