What protein does SMAD4 produce?
What protein does SMAD4 produce?
SMAD4, also called SMAD family member 4, Mothers against decapentaplegic homolog 4, or DPC4 (Deleted in Pancreatic Cancer-4) is a highly conserved protein present in all metazoans. It belongs to the SMAD family of transcription factor proteins, which act as mediators of TGF-β signal transduction.
What is the role of SMAD4?
In the nucleus, the SMAD protein complex binds to specific areas of DNA where it controls the activity of particular genes and regulates cell growth and division (proliferation). By controlling these cellular processes, the SMAD4 protein is involved in the development of many body systems.
How are SMADs activated?
Smads are localized at the cell surface by Smad anchor for receptor activation (SARA) proteins, placing them in proximity of type 1 receptor kinases to facilitate phosphorylation.
Is PTEN an oncogene?
Phosphatase and tensin homolog (PTEN) is a phosphatase in humans and is encoded by the PTEN gene. Mutations of this gene are a step in the development of many cancers, specifically glioblastoma, lung cancer, breast cancer, and prostate cancer….PTEN (gene)
| RNA expression pattern | |
|---|---|
| BioGPS | n/a |
What does MLH1 stand for?
The name MLH1 stands for “MutL homolog 1.” The gene is located on chromosome 3. The MLH1 gene protein plays an important role in repairing DNA damage.
What is Smad slang?
SMAD means “Sad and mad.”
What was Smad?
The Soviet Military Administration in Germany (Russian: Советская военная администрация в Германии, СВАГ; Sovyetskaya Voyennaya Administratsiya v Germanii, SVAG; German: Sowjetische Militäradministration in Deutschland, SMAD) was the Soviet military government, headquartered in Berlin-Karlshorst, that directly ruled …
How many DNA binding domains do SMADs have?
two conserved
SMAD proteins are characterized by two conserved domains: namely, the amino- terminal Mad-homology domain 1 (MH1) and the carboxyl-terminal Mad-homology domain 2 (MH2).
What are the symptoms of Loeys Dietz syndrome?
What Are the Symptoms of Loeys-Dietz Syndrome?
- Blue tinge in the whites of the eyes.
- Submucous cleft palate (a hole in the roof of the mouth underneath the skin)
- Early fusion of the skull bones (craniosynostosis)
- Eyes that are widely spaced or slant downwards.
- Small or receding chin.
