What part of the bone does osteoporosis affect?

Osteoporotic bone breaks are most likely to occur in the hip, spine or wrist, but other bones can break too. In addition to causing permanent pain, osteoporosis causes some patients to lose height. When osteoporosis affects vertebrae, or the bones of the spine, it often leads to a stooped or hunched posture.

What bones are most affected by osteoporosis?

Osteoporosis-related fractures most commonly occur in the hip, wrist or spine. Bone is living tissue that is constantly being broken down and replaced. Osteoporosis occurs when the creation of new bone doesn’t keep up with the loss of old bone.

What destroys bone matrix?

Osteoclasts are unique cells that destroy the mineralized matrix of the skeleton.

What causes bone matrix?

Cells in our bones are responsible for bone formation, resorption, maintenance and (re-)modelling: Osteoblasts: These cells are derived from mesenchymal stem cells and are responsible for bone matrix synthesis and its subsequent mineralization.

What is matrix of bone?

Bone matrix (also known as osteoid) consists of about 33% organic matter (mostly Type I collagen) and 67% inorganic matter (calcium phosphate, mostly hydroxyapatite crystals). The osteoblasts occur as simple, epithelial-like layer at the developing bone surface.

How osteoporosis affects the structure and function of spongy bone?

Understanding Osteoporosis Osteoporosis will develop when you are unable to produce enough new bone tissue to replace old and lost tissue. As osteoporosis develops, your bone structure changes. The holes in the spongy bone grow larger and more numerous. As a result, the bones become brittle and prone to fracture.

What are the three stages of osteoporosis?

The stages of Osteoporosis

  • Osteoblasts vs Osteoclasts. Active Osteoblasts.
  • Peak bone density and the first stages of osteopenia and osteoporosis.
  • The second stage of osteopenia and osteoporosis.
  • The third stage of osteopenia and osteoporosis.
  • The fourth stage of osteopenia and osteoporosis.

What is bone matrix?

Bone matrix is a composite material consisting of organic and inorganic components. The organic matrix makes up ∼20% of the wet weight of bone and is comprised primarily of collagen.

What is responsible for replacing bone matrix?

While bone resorption is performed by large immune cells called osteoclasts, osteoblasts, a type of specialized connective tissue-related cells, is responsible for making new bone. Bone remodeling is impaired in osteopetrosis due to inadequate osteoclast function and impairment of bone resorption.

What maintains bone matrix?

There are three types of cells that contribute to bone homeostasis. Osteoblasts are bone-forming cell, osteoclasts resorb or break down bone, and osteocytes are mature bone cells. An equilibrium between osteoblasts and osteoclasts maintains bone tissue.

Where is bone matrix found?

The bone matrix is that part of the bone tissue and forms most of the mass of the bone. It is comprised of organic and inorganic substances. The organic component of the bone matrix includes the collagen and ground substance whereas the inorganic component is the inorganic bone salts, mainly the hydroxyapatite.