What labs needs to be monitor with clozapine?

Monitoring clozapine patients Baseline blood tests should check white cell count, troponins, CRP and possibly BNP3. Patients with a history of cardiac disease or abnormal cardiac findings on examination (such as QT prolongation) should be referred to a cardiologist7.

What is red result for clozapine?

The clozapine monitoring system uses traffic light coding to grade the results from your blood tests i.e. ‘red’, ‘amber’ and a ‘green’: Red means your white blood cells count is much lower than normal. You will need to stop taking clozapine straight away.

Can clozapine cause elevated WBC?

Unfortunately, clozapine is also associated with a number of adverse effects, with agranulocytosis being one of the chief concerns. Interestingly, patients who receive clozapine treatment may occasionally experience elevations in their total white blood cell count (WBC).

What labs need to be monitored with antipsychotics?

Recommended assessments at baseline include: pulse, blood pressure, weight, height, calculation of body mass index, fasting blood glucose or hemoglobin A1C, lipid panel, CBC, electrolytes, renal function tests, hepatic function tests, TSH.

When should clozapine levels be checked?

Clozapine reaches a steady-state concentration at 5-7 days. Levels should be drawn 12 hours (± 2 h) after the last dose. Clozapine blood levels are correlated with both clozapine effectiveness and side effects.

Does clozapine cause neutropenia?

Clozapine can induce two clinically distinct types of neutropenia [19]. The first type is a mild to moderate neutropenia (neutrophil count below 1.5 ∗ 103/μL but not lower than 0.5 ∗ 103/μL) which occurs in 1.8% of treated patients. When clozapine is discontinued, recovery is rapid (2–8 days).

Is agranulocytosis the same as neutropenia?

Also known as granulocytopenia, agranulocytosis is a severe form of neutropenia. Neutropenia is lower-than-normal levels of white blood cells.

Does clozapine lower WBC?

The stable but low total WBC and neutrophil counts during clozapine therapy can, with hindsight, be explained as being due to a constant but mild clozapine-induced suppression of WBCs during the 19 years of clozapine treatment.

Why does clozapine cause leukocytosis?

The mechanism underlying how clozapine causes leukocytosis remains unknown (4). One possibility is that clozapine may stimulate the release of certain cytokines, including TNF, IL-2, IL-6, and G-CSF (5). Other possible risk factors may be smoking, being male, and the use of lithium (6).

What labs do you monitor for olanzapine?

You will have your weight measured regularly. You may also need to have blood tests to check your kidneys, liver, cholesterol and glucose levels. You may also have your blood pressure measured and an ECG test to check your heart rate.

What to check before giving antipsychotics?

You should only need to have an ECG before being prescribed antipsychotics if: you have high blood pressure or any other symptom that may relate to your heart. you have a family history of heart problems.