What is undifferentiated embryonal sarcoma of the liver?

Undifferentiated embryonal sarcoma of the liver (UESL) is a rare form of liver cancer that occurs mainly in children, usually between ages 5 and 10, but also well into adolescence. It is the third most common type of primary liver cancer in kids, after hepatoblastoma and hepatocellular carcinoma.

What is sarcoma of the liver?

Sarcomas are rare malignant tumors arising from mesenchymal cells exhibiting heterogeneous histological patterns. In the liver, these tumors represent only 0.1% to 2% of primary hepatic cancer. In most patients, causative factors remain unclear. Primary symptoms are nonspecific.

Is liver cancer considered sarcoma?

Undifferentiated Liver Sarcoma, also known as Undifferentiated Embryonal Sarcoma of the Liver, is a rare, highly malignant neoplasm which affects mostly the pediatric population, although a few cases have been reported in adults. It accounts for about 13% of pediatric hepatic malignancies.

What is the survival rate of hepatoblastoma?

Hepatoblastoma Prognosis Survival rates have reached 80-90 percent. This rate depends upon staging at diagnosis. Patients with fully resected tumors have a greater than 85 percent chance of survival. The rate is about 60 percent for those with metastatic disease that responds to chemo.

What is embryonal carcinoma?

Embryonal carcinoma is a type of testicular cancer, which is cancer that starts in the testicles, the male reproductive glands located in the scrotum. It most often develops in young and middle-aged men. It tends to grow rapidly and spread outside the testicle.

Is sarcoma terminal?

A sarcoma is considered stage IV when it has spread to distant parts of the body. Stage IV sarcomas are rarely curable. But some patients may be cured if the main (primary) tumor and all of the areas of cancer spread (metastases) can be removed by surgery. The best success rate is when it has spread only to the lungs.

Are sarcomas aggressive?

It is aggressive and often spreads to other areas of the body, particularly the lungs or liver. These tumors can cause pain and a mass can usually be felt in the abdomen.

Can sarcoma spread to the liver?

The sarcoma often spreads to the liver, which is the predominant initial site of failure for abdominal and pelvic primary sarcomas, occurring in 64%–70% of patients (1, 2, 3, 4, 5), often months to years after resection of the primary. Metastatic liver disease is a major determinant of patient survival.

How can you tell you have liver cancer?

When signs and symptoms do appear, they may include:

  • Losing weight without trying.
  • Loss of appetite.
  • Upper abdominal pain.
  • Nausea and vomiting.
  • General weakness and fatigue.
  • Abdominal swelling.
  • Yellow discoloration of your skin and the whites of your eyes (jaundice)
  • White, chalky stools.

Are all liver tumors cancerous?

Because the liver is made up of several different types of cells, several types of tumors can form there. Some of these are benign (noncancerous), and some are cancerous and can spread to other parts of the body (metastasize). These tumors have different causes and are treated differently.

Is hepatoblastoma curable?

As with most cancers, cure rates for children are much higher than for adult cancers. More than half of the children with hepatoblastoma are cured, and for children with small tumors only in the liver the prospects are even better.

What is embryonal sarcoma of the liver (uesl)?

Background: Undifferentiated embryonal sarcoma of the liver (UESL) is a rare liver malignancy originating from primary mesenchymal tissue. The clinical manifestations, laboratory tests, and imaging examinations of the disease lack specificity and the preoperative misdiagnosis rate is high.

What are the treatment options for embryonal sarcoma of the liver?

Long-term survival outcomes of undifferentiated embryonal sarcoma of the liver: a pooled analysis of 308 patients Radical hepatectomy combined chemotherapy should be considered as the preferred treatment option for USEL. Liver transplantation appears to be a reasonable alternative for unresectable disease.

Do Kaplan-Meier curves differ between children and adults with embryonal sarcoma?

Kaplan-Meier curves demonstrating differences in overall survival for undifferentiated embryonal sarcoma of the liver between children and adults (A), between patients with and without metastasis at diagnosis (B), between patients undergoing surgery or not (C), and between patients receiving chemotherapy or not (D).

What is the prognosis of upper esophageal spleen cancer?

During the follow-up, the maximum survival time was shown to be 11 years and minimum survival time was 6 mo. Six adult patients relapsed late after surgery and all of them died. Conclusion: Preoperative imaging examination for UESL has a high misdiagnosis rate.